About: Cystatins of the parasitic nematodes from the genus Trichinella     Goto   Sponge   NotDistinct   Permalink

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  • The nematodes of the genus Trichinella are intracellular parasites of small intestine and skeletal muscle cells. They can infect a broad range of worldwide distributed hosts like birds, reptiles and mammals. All Trichinella spp. are zoonotic but only six of twelve genotypes have been detected in humans, causing the trichinellosis - a serious, sometimes fatal, human disease, which has been documented in 55 countries of the World. Our study is focused on characterization of composition of excretory-secretory products (ESP) from L1 muscle larvae of three trichinella species - Trichinella spiralis, T. britovi and T. pseudospiralis. The dominant components of L1 ESP are cystatins. These proteins are a reversible inhibitors of proteolytics enzymes - cystein peptideases and they are involved in many relevant biological processes such as development, growth, digestion and migration of parasites and suppression of host immune responses.
  • The nematodes of the genus Trichinella are intracellular parasites of small intestine and skeletal muscle cells. They can infect a broad range of worldwide distributed hosts like birds, reptiles and mammals. All Trichinella spp. are zoonotic but only six of twelve genotypes have been detected in humans, causing the trichinellosis - a serious, sometimes fatal, human disease, which has been documented in 55 countries of the World. Our study is focused on characterization of composition of excretory-secretory products (ESP) from L1 muscle larvae of three trichinella species - Trichinella spiralis, T. britovi and T. pseudospiralis. The dominant components of L1 ESP are cystatins. These proteins are a reversible inhibitors of proteolytics enzymes - cystein peptideases and they are involved in many relevant biological processes such as development, growth, digestion and migration of parasites and suppression of host immune responses. (en)
Title
  • Cystatins of the parasitic nematodes from the genus Trichinella
  • Cystatins of the parasitic nematodes from the genus Trichinella (en)
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  • Cystatins of the parasitic nematodes from the genus Trichinella
  • Cystatins of the parasitic nematodes from the genus Trichinella (en)
skos:notation
  • RIV/00216224:14310/14:00075464!RIV15-MSM-14310___
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  • RIV/00216224:14310/14:00075464
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  • Trichinella; multi cystatin-like domain gene; Trichinella spiralis; Trichinella britovi; Trichinella pseudospiralis (en)
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  • Kašný, Martin
  • Ilgová, Jana
  • Koudela, Břetislav
  • Gelnar, Milan
  • Šrámová, Eliška
  • Škorpíková, Lucie
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  • 14310
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