About: Identification of key regulatory metabolites in hESCs by MALDI-TOF-MS

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The ability of human embryonic stem cells (hESC) to differentiate into any cell type of human body presents a tool for regenerative medicine raising the need for advanced cultivation and differentiation protocols. Metabolic homeostasis in stem cells is shown to be different from that in somatic cells. To meet their energetic demands stem cells rely mostly on glycolysis rather than on oxidative phosphorylation. Energy metabolism contributes to molecular mechanisms controlling stem cell identity, selfrenewal and differentiation. In this context, clear understanding of how cell fate decisions and metabolic processes are intertwined is essential for identification of key regulatory nodes capable of differential stem cell fate choice regulation. Matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI TOF MS) has been proved to be a powerful tool to study proteomic and metabolic fingerprints of both bacterial and mammalian cell lines. The ability of human embryonic stem cells (hESC) to differentiate into any cell type of human body presents a tool for regenerative medicine raising the need for advanced cultivation and differentiation protocols. Metabolic homeostasis in stem cells is shown to be different from that in somatic cells. To meet their energetic demands stem cells rely mostly on glycolysis rather than on oxidative phosphorylation. Energy metabolism contributes to molecular mechanisms controlling stem cell identity, selfrenewal and differentiation. In this context, clear understanding of how cell fate decisions and metabolic processes are intertwined is essential for identification of key regulatory nodes capable of differential stem cell fate choice regulation. Matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI TOF MS) has been proved to be a powerful tool to study proteomic and metabolic fingerprints of both bacterial and mammalian cell lines. (en)
Title	Identification of key regulatory metabolites in hESCs by MALDI-TOF-MS Identification of key regulatory metabolites in hESCs by MALDI-TOF-MS (en)
skos:prefLabel	Identification of key regulatory metabolites in hESCs by MALDI-TOF-MS Identification of key regulatory metabolites in hESCs by MALDI-TOF-MS (en)
skos:notation	RIV/00216224:14310/14:00074304!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0086), P(GA13-19910S)
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Salykin, Anton Havel, Josef Rotrekl, Vladimír Dvořák, Petr Amato, Filippo
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	20291
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00074304
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	regulatory metabolites; MALDI-TOF-MS; mass spectrometry (en)
http://linked.open.../riv/klicoveSlovo	mass spectrometry MALDI-TOF-MS regulatory metabolites
http://linked.open...ontrolniKodProRIV	[843AFE7C7CDC]
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional R&D center for low-cost plasma and nanotechnology surface modifications Modeling DMD-related dilated cardiomyopathy using induced pluripotent stem cells-derived cardiomyocytes
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Amato, Filippo Dvořák, Petr Havel, Josef Salykin, Anton Rotrekl, Vladimír
http://localhost/t...ganizacniJednotka	14310

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