About: Computational Tools for Designing and Engineering Enzymes.

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About: Computational Tools for Designing and Engineering Enzymes. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Protein engineering strategies aimed at constructing enzymes with novel or improved activities, specificities, and stabilities greatly benefit from in silico methods. Computational methods can be principally grouped into three main categories: (i) bioinformatics, (ii) molecular modelling, and (iii) de novo design. Particularly de novo protein design is experiencing rapid development, resulting in more robust and reliable predictions. A recent trend in the field is to combine several computational approaches in an interactive manner and to complement them with structural analysis and directed evolution. A detailed investigation of designed catalysts provides valuable information on the structural basis of molecular recognition, biochemical catalysis, and natural protein evolution. Protein engineering strategies aimed at constructing enzymes with novel or improved activities, specificities, and stabilities greatly benefit from in silico methods. Computational methods can be principally grouped into three main categories: (i) bioinformatics, (ii) molecular modelling, and (iii) de novo design. Particularly de novo protein design is experiencing rapid development, resulting in more robust and reliable predictions. A recent trend in the field is to combine several computational approaches in an interactive manner and to complement them with structural analysis and directed evolution. A detailed investigation of designed catalysts provides valuable information on the structural basis of molecular recognition, biochemical catalysis, and natural protein evolution. (en)
Title	Computational Tools for Designing and Engineering Enzymes. Computational Tools for Designing and Engineering Enzymes. (en)
skos:prefLabel	Computational Tools for Designing and Engineering Enzymes. Computational Tools for Designing and Engineering Enzymes. (en)
skos:notation	RIV/00216224:14310/14:00074212!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0001/01/01), P(EE2.3.30.0037), P(GAP503/12/0572)
http://linked.open...iv/cisloPeriodika	april
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Damborský, Jiří Brezovský, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	8484
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00074212
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Enzymes; engineering enzyme; ROSETTA and ORBIT (en)
http://linked.open.../riv/klicoveSlovo	Enzymes ROSETTA and ORBIT engineering enzyme
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[26E3178F7848]
http://linked.open...i/riv/nazevZdroje	Current Opinion in Chemical Biology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Employment of Best Young Scientists for International Cooperation Empowerment Construction of a synthetic metabolic pathway for degradation of important environmental pollutant using protein and metabolic engineering CETOCOEN
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Brezovský, Jan Damborský, Jiří
http://linked.open...ain/vavai/riv/wos	000336471600004
issn	1367-5931
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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