About: Recombinant antibodies for in vivo applications

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.structbio.org/index.php/conferences/25-xiidiscussions
Description	Interactions between biomolecules constitute the core of biological functions. In protein–protein interactions, specificity plays a key role and many proteins have evolved into extraordinarily precise molecular machines. The multistep phosphorylation pathway of the cytokinin signaling in plants is involving promiscuous protein-protein interactions, allowing the plasticity of the plant cell response to environmental and developmental stimuli. We have developed a recombinant antibody which is able to precisely bind to a specific protein from the phosporylation pathway in vivo. Hereinafter this protein is not phosphorylated after the signal perception and therefore the message is not delivered to the nucleus to commit the reaction of the plant. To accomplish a successful selection of the recombinant antibody, we have developed a in vivo selection method. This method allows targeting of recombinant antibodies for a precise activity. Along the way of developing our method, we came to several conclusions. Interactions between biomolecules constitute the core of biological functions. In protein–protein interactions, specificity plays a key role and many proteins have evolved into extraordinarily precise molecular machines. The multistep phosphorylation pathway of the cytokinin signaling in plants is involving promiscuous protein-protein interactions, allowing the plasticity of the plant cell response to environmental and developmental stimuli. We have developed a recombinant antibody which is able to precisely bind to a specific protein from the phosporylation pathway in vivo. Hereinafter this protein is not phosphorylated after the signal perception and therefore the message is not delivered to the nucleus to commit the reaction of the plant. To accomplish a successful selection of the recombinant antibody, we have developed a in vivo selection method. This method allows targeting of recombinant antibodies for a precise activity. Along the way of developing our method, we came to several conclusions. (en)
Title	Recombinant antibodies for in vivo applications Recombinant antibodies for in vivo applications (en)
skos:prefLabel	Recombinant antibodies for in vivo applications Recombinant antibodies for in vivo applications (en)
skos:notation	RIV/00216224:14310/14:00073670!RIV15-GA0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA521/09/1699)
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zábrady, Matej
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	41610
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00073670
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	recombinant antibodies in vivo inhibition yeast two=hybrid (en)
http://linked.open.../riv/klicoveSlovo	recombinant antibodies in vivo inhibition yeast two=hybrid
http://linked.open...ontrolniKodProRIV	[2F91846ED12C]
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunomodulation as a functional proteomics tool for cytokinin signaling study in Arabidopsis thaliana
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Zábrady, Matej
http://localhost/t...ganizacniJednotka	14310

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