About: Cysteine peptidase inhibitors of helminths

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Investigating the functions of various bioactive molecules produced by parasites expands our understanding of the principles of host-parasite interaction. Several of these compounds were proven to play a key role in a manipulation of the host immune system and thus maximizing the parasite success; among them also the cysteine peptidase inhibitors (CPI) were recorded. Our work is focused on characterization of the properties of CPI expressed by four helminth model species representing four big taxonomic groups – Monogenea, Cestoda, Trematoda and Nematoda. Prior to the functional analysis we searched the transcriptomic and/or genomic data of Eudiplozoon nipponicum, Hymenolepis diminuta, Fascioloides magna and Trichinella spiralis for the presence of conserved cystatin domains. We identified distinct families of CPI (stefins, cystatins and kininogens) and observed differences among the studied species. We designed specific/degenerate primers; amplified, cloned and sequenced the selected genes. Investigating the functions of various bioactive molecules produced by parasites expands our understanding of the principles of host-parasite interaction. Several of these compounds were proven to play a key role in a manipulation of the host immune system and thus maximizing the parasite success; among them also the cysteine peptidase inhibitors (CPI) were recorded. Our work is focused on characterization of the properties of CPI expressed by four helminth model species representing four big taxonomic groups – Monogenea, Cestoda, Trematoda and Nematoda. Prior to the functional analysis we searched the transcriptomic and/or genomic data of Eudiplozoon nipponicum, Hymenolepis diminuta, Fascioloides magna and Trichinella spiralis for the presence of conserved cystatin domains. We identified distinct families of CPI (stefins, cystatins and kininogens) and observed differences among the studied species. We designed specific/degenerate primers; amplified, cloned and sequenced the selected genes. (en)
Title	Cysteine peptidase inhibitors of helminths Cysteine peptidase inhibitors of helminths (en)
skos:prefLabel	Cysteine peptidase inhibitors of helminths Cysteine peptidase inhibitors of helminths (en)
skos:notation	RIV/00216224:14310/14:00073621!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GAP506/12/1258), P(GBP505/12/G112), S
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kašný, Martin Ilgová, Jana Gelnar, Milan Koudela, Břetislav
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	9531
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00073621
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cysteine peptidase inhibitors; helminths; immunomodulation (en)
http://linked.open.../riv/klicoveSlovo	helminths immunomodulation cysteine peptidase inhibitors
http://linked.open...ontrolniKodProRIV	[6009BC213CE1]
http://linked.open...in/vavai/riv/obor	EG
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	ECIP - European Centre of Ichtyoparasitology Host-parasite interactions in blood-feeding diplozoid monogeneans: Investigation of highly specialized adaptation for parasitism
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Kašný, Martin Ilgová, Jana Koudela, Břetislav Gelnar, Milan
http://localhost/t...ganizacniJednotka	14310

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