About: Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The present invention relates to a method of thermostabilization of a protein and/or stabilization of a protein towards organic solvents wherein the protein contains access routes, wherein at least one amino acid in the bottleneck of the access route of the protein is mutated. Preferably, the method comprises the steps of identification of amino acids forming the bottleneck of the access routes, wherein said amino acids control the exchange of the solvent between the buried protein core and the surrounding environment and/or in the packing of the amino acids inside the access route; modification of the amino acids determined in the previous step so that the packing of the amino acids inside the tunnel is improved and the access route prevents the access of the undesired solvent molecules to the protein core, while it allows the passage of the compounds necessary at the protein core to enable the protein to perform its biological function. The present invention relates to a method of thermostabilization of a protein and/or stabilization of a protein towards organic solvents wherein the protein contains access routes, wherein at least one amino acid in the bottleneck of the access route of the protein is mutated. Preferably, the method comprises the steps of identification of amino acids forming the bottleneck of the access routes, wherein said amino acids control the exchange of the solvent between the buried protein core and the surrounding environment and/or in the packing of the amino acids inside the access route; modification of the amino acids determined in the previous step so that the packing of the amino acids inside the tunnel is improved and the access route prevents the access of the undesired solvent molecules to the protein core, while it allows the passage of the compounds necessary at the protein core to enable the protein to perform its biological function. (en)
Title	Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents (en)
skos:prefLabel	Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents (en)
skos:notation	RIV/00216224:14310/13:00072736!RIV14-MSM-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED0001/01/01)
http://linked.open...cisloPatentuVzoru	US 8,580,932
http://linked.open...eleniPatentuVzoru	2013-11-12 (xsd:date)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Koudeláková, Táňa Prokop, Zbyněk Štěpánková, Veronika Damborský, Jiří Brezovský, Jan Chaloupková, Radka
http://linked.open.../riv/druhVysledku	P - Patent
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	87569
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00072736
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Thermostabilization; Protein Stabilization; Organic Solvents (en)
http://linked.open.../riv/klicoveSlovo	Organic Solvents Protein Stabilization Thermostabilization
http://linked.open...ontrolniKodProRIV	[B87F20DF72ED]
http://linked.open.../licencniPoplatek	Z - Poskytovatel licence na výsledek nepožaduje v některých případech licenční poplatek
http://linked.open...ydaniPatentuVzoru	Alexandria
http://linked.open...atelePatentuVzoru	United States Patent and Trademark Office (USPTO)
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	CETOCOEN
http://linked.open...UplatneniVysledku	2013
http://linked.open...ydaniPatentuVzoru	US - Spojené státy americké
http://linked.open...iv/tvurceVysledku	Brezovský, Jan Chaloupková, Radka Chovancová, Eva Damborský, Jiří Koudeláková, Táňa Prokop, Zbyněk Štěpánková, Veronika Gora, Artur Wiktor
http://linked.open...mniOchranaPatentu	B - USTPO (Úřad pro patenty a ochranné známky USA)
http://linked.open...avai/riv/vlastnik	MU
http://linked.open...itiJinymSubjektem	A - Nabytí licence je nutné vždy
http://linked.open...uzitiPatentuVzoru	B - Využívaný třetí stranou na základě licenční smlouvy
http://linked.open...stnikPatentuVzoru	MU
http://localhost/t...ganizacniJednotka	14310

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