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Description
  • ATP-binding transporters (ABC-t) play various roles in regulation of organism function and homeostasis from prokaryote to mammals. ABC-t mediate transport mainly of lipophilic substances through cellular membranes. These transporters protect stem cells against toxic substances of either endogenous, or importantly, exogenous origin. These transporters are called ABC-t associated with multi-drug resistance (MDR), according to their role in multidrug resistance to pharmacotherapy. High level of ABC-t expression is a typical feature of stem cells and many types of cancer stem cells. Particularly, ABCB1/P-glycoprotein/MDR1, ABCC1/multidrug resistance-associated protein 1 (MRP1), and ABCG2/BCRP (Breast cancer resistance protein);. However, substrates of ABC-t/MDR are not only toxins, but also important signaling molecules as well as leukotrienes and/or glutathione conjugates; and porphyrins, which mediate balance in intracellular oxidation-reduction processing.
  • ATP-binding transporters (ABC-t) play various roles in regulation of organism function and homeostasis from prokaryote to mammals. ABC-t mediate transport mainly of lipophilic substances through cellular membranes. These transporters protect stem cells against toxic substances of either endogenous, or importantly, exogenous origin. These transporters are called ABC-t associated with multi-drug resistance (MDR), according to their role in multidrug resistance to pharmacotherapy. High level of ABC-t expression is a typical feature of stem cells and many types of cancer stem cells. Particularly, ABCB1/P-glycoprotein/MDR1, ABCC1/multidrug resistance-associated protein 1 (MRP1), and ABCG2/BCRP (Breast cancer resistance protein);. However, substrates of ABC-t/MDR are not only toxins, but also important signaling molecules as well as leukotrienes and/or glutathione conjugates; and porphyrins, which mediate balance in intracellular oxidation-reduction processing. (en)
Title
  • The role of ABC transporters associated with multidrug resistance in stem cells
  • The role of ABC transporters associated with multidrug resistance in stem cells (en)
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  • The role of ABC transporters associated with multidrug resistance in stem cells
  • The role of ABC transporters associated with multidrug resistance in stem cells (en)
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  • RIV/00216224:14310/13:00070749!RIV14-MSM-14310___
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  • RIV/00216224:14310/13:00070749
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  • ABC-transporters neural stem cells (en)
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  • Kučera, Jan
  • Pacherník, Jiří
  • Večeřa, Josef
  • Lánová, Martina
  • Medalová, Jiřina
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  • 14310
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