About: Strategies for Stabilization and Activation of Biocatalysts in Organic Solvents

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	One of the major barriers to the use of enzymes in industrial biotechnology is their insufficient stability under processing conditions. The use of organic solvent systems instead of aqueous media for enzymatic reactions offers numerous advantages, such as increased solubility of hydrophobic substrates or suppression of water-dependent side reactions. For example, reverse hydrolysis reactions that form esters from acids and alcohols can become thermodynamically favourable in organic solution. However, organic solvents often inactivate enzymes. Industry and academia have devoted considerable effort into developing effective strategies to enhance the lifetime of enzymes in the presence of organic solvents. One of the major barriers to the use of enzymes in industrial biotechnology is their insufficient stability under processing conditions. The use of organic solvent systems instead of aqueous media for enzymatic reactions offers numerous advantages, such as increased solubility of hydrophobic substrates or suppression of water-dependent side reactions. For example, reverse hydrolysis reactions that form esters from acids and alcohols can become thermodynamically favourable in organic solution. However, organic solvents often inactivate enzymes. Industry and academia have devoted considerable effort into developing effective strategies to enhance the lifetime of enzymes in the presence of organic solvents. (en)
Title	Strategies for Stabilization and Activation of Biocatalysts in Organic Solvents Strategies for Stabilization and Activation of Biocatalysts in Organic Solvents (en)
skos:prefLabel	Strategies for Stabilization and Activation of Biocatalysts in Organic Solvents Strategies for Stabilization and Activation of Biocatalysts in Organic Solvents (en)
skos:notation	RIV/00216224:14310/13:00067016!RIV14-GA0-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP207/12/0775), P(GAP503/12/0572)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Koudeláková, Táňa Prokop, Zbyněk Štěpánková, Veronika Damborský, Jiří Chaloupková, Radka Bidmanová, Šárka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	108149
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00067016
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biocatalysis; enzyme stability; organic solvents; chemical modi fi cations; enzyme immobilization; protein engineering (en)
http://linked.open.../riv/klicoveSlovo	organic solvents biocatalysis chemical modi fi cations enzyme stability enzyme immobilization protein engineering
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BD79146CDFB0]
http://linked.open...i/riv/nazevZdroje	ACS Catalysis
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Strukturně-funkční vztahy haloalkan dehalogenas Construction of a synthetic metabolic pathway for degradation of important environmental pollutant using protein and metabolic engineering
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	3
http://linked.open...iv/tvurceVysledku	Bidmanová, Šárka Chaloupková, Radka Damborský, Jiří Koudeláková, Táňa Prokop, Zbyněk Štěpánková, Veronika
http://linked.open...ain/vavai/riv/wos	000328231400019
issn	2155-5435
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/cs400684x
http://localhost/t...ganizacniJednotka	14310

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