About: Fish MHC genes - quality vs quantity

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Even if the role, variability and evolutionary mechanism of selection of genes of major histocompatibility complex (MHC genes) has been proved for several times to be very important in immunoecological studies and in investigation of associations between multiple parasites and host immunocompetence in cyprinids, the question of quantitative expression of these genes stays still unanswered. Our research reveals that not only “quality” (genomic variability or allelic richness) but also “quantity” of these genes (active gene expression and its level) may play an important role in host-parasite interactions and may be useful for evolutionary and population studies. By utilizing two modern approaches (high resolution melting analysis – HRM and quantitative PCR – qPCR) we obtained notable primary results that could supplement or possibly stand in the analysis by classical methods in MHC research (CE-SSCP, automatic sequencing based on Sanger technology or 454 clonal pyrosequencing). Even if the role, variability and evolutionary mechanism of selection of genes of major histocompatibility complex (MHC genes) has been proved for several times to be very important in immunoecological studies and in investigation of associations between multiple parasites and host immunocompetence in cyprinids, the question of quantitative expression of these genes stays still unanswered. Our research reveals that not only “quality” (genomic variability or allelic richness) but also “quantity” of these genes (active gene expression and its level) may play an important role in host-parasite interactions and may be useful for evolutionary and population studies. By utilizing two modern approaches (high resolution melting analysis – HRM and quantitative PCR – qPCR) we obtained notable primary results that could supplement or possibly stand in the analysis by classical methods in MHC research (CE-SSCP, automatic sequencing based on Sanger technology or 454 clonal pyrosequencing). (en)
Title	Fish MHC genes - quality vs quantity Fish MHC genes - quality vs quantity (en)
skos:prefLabel	Fish MHC genes - quality vs quantity Fish MHC genes - quality vs quantity (en)
skos:notation	RIV/00216224:14310/13:00067000!RIV14-GA0-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GBP505/12/G112)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Civáňová, Kristína
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	75229
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00067000
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MHC genes-qPCR-cyprinidae (en)
http://linked.open.../riv/klicoveSlovo	MHC genes-qPCR-cyprinidae
http://linked.open...ontrolniKodProRIV	[A2ECA6121D36]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	ECIP - European Centre of Ichtyoparasitology
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Civáňová, Kristína
http://localhost/t...ganizacniJednotka	14310

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