About: Characterization of stefis from parasitic helminths

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Stefins together with cystatins and kininogens belong to a large family of cysteine peptidase inhibitors. These molecules participate in regulation of various biological processes and have a crucial role as modulators of host immune response (e.g. antigen processing and presentation, nitric oxide production, etc.). Stefins are primarily located intracellularly, but they can be found in high concentrations also in excretory/secretory products of helminths and thus mediating the parasite-host molecular communication. Our study is focused on molecular, biochemical and immunological characterization of stefins which were identified in four parasitic organisms representing the four main groups of helminths: Fascioloides magna (Trematoda), Hymenolepis diminuta (Cestoda), Eudiplozoon nipponicum (Monogenea) and Trichinella spiralis (Nematoda). Considering the differences in biology of these parasites (e.g. life cycle, localization, nutrition) we expect possible divergence in stefin functions. Stefins together with cystatins and kininogens belong to a large family of cysteine peptidase inhibitors. These molecules participate in regulation of various biological processes and have a crucial role as modulators of host immune response (e.g. antigen processing and presentation, nitric oxide production, etc.). Stefins are primarily located intracellularly, but they can be found in high concentrations also in excretory/secretory products of helminths and thus mediating the parasite-host molecular communication. Our study is focused on molecular, biochemical and immunological characterization of stefins which were identified in four parasitic organisms representing the four main groups of helminths: Fascioloides magna (Trematoda), Hymenolepis diminuta (Cestoda), Eudiplozoon nipponicum (Monogenea) and Trichinella spiralis (Nematoda). Considering the differences in biology of these parasites (e.g. life cycle, localization, nutrition) we expect possible divergence in stefin functions. (en)
Title	Characterization of stefis from parasitic helminths Characterization of stefis from parasitic helminths (en)
skos:prefLabel	Characterization of stefis from parasitic helminths Characterization of stefis from parasitic helminths (en)
skos:notation	RIV/00216224:14310/13:00066890!RIV14-MSM-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GBP505/12/G112), S
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kašný, Martin Ilgová, Jana Gelnar, Milan Šrámová, Eliška
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	65108
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00066890
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	stefins; helminths; cystatins (en)
http://linked.open.../riv/klicoveSlovo	helminths cystatins stefins
http://linked.open...ontrolniKodProRIV	[05D47D741E3D]
http://linked.open...in/vavai/riv/obor	EG
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	ECIP - European Centre of Ichtyoparasitology
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Kašný, Martin Ilgová, Jana Koudela, Břetislav Gelnar, Milan Šrámová, Eliška
http://localhost/t...ganizacniJednotka	14310

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