About: Haloalkane dehalogenases: Biotechnological applications

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Haloalkane dehalogenases (EC 3.8.1.5) are alfa/beta-hydrolases cleaving a carbon-halogen bond in more than hundred halogenated aliphatic and cyclic compounds. Due to interesting chemistry, broad substrate specificity and high robustness, the members of this enzyme family have been employed in several practical applications: (i) biocatalytic preparation of optically pure building-blocks for organic synthesis, (ii) recycling of by-products from chemical processes, (iii) bioremediation of toxic environmental pollutants, (iv) decontamination of warfare agents, (v) biosensing of environmental pollutants, and (vi) protein tagging for cell imaging and protein analysis. The review discusses these applications in the context of biochemical properties of individual enzymes, when nine out of seventeen characterized enzymes possess properties suitable for practical applications. Haloalkane dehalogenases (EC 3.8.1.5) are alfa/beta-hydrolases cleaving a carbon-halogen bond in more than hundred halogenated aliphatic and cyclic compounds. Due to interesting chemistry, broad substrate specificity and high robustness, the members of this enzyme family have been employed in several practical applications: (i) biocatalytic preparation of optically pure building-blocks for organic synthesis, (ii) recycling of by-products from chemical processes, (iii) bioremediation of toxic environmental pollutants, (iv) decontamination of warfare agents, (v) biosensing of environmental pollutants, and (vi) protein tagging for cell imaging and protein analysis. The review discusses these applications in the context of biochemical properties of individual enzymes, when nine out of seventeen characterized enzymes possess properties suitable for practical applications. (en)
Title	Haloalkane dehalogenases: Biotechnological applications Haloalkane dehalogenases: Biotechnological applications (en)
skos:prefLabel	Haloalkane dehalogenases: Biotechnological applications Haloalkane dehalogenases: Biotechnological applications (en)
skos:notation	RIV/00216224:14310/13:00066570!RIV14-MSM-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0001/01/01), P(GA203/08/0114), P(GAP207/12/0775), P(GAP503/12/0572), P(LG13010)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Koudeláková, Táňa Pavelka, Antonín Damborský, Jiří Dvořák, Pavel Chaloupková, Radka Bidmanová, Šárka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	77011
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00066570
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Biocatalysis; Biodegradation; Biosensors; Cell imaging; Protein analysis (en)
http://linked.open.../riv/klicoveSlovo	Biosensors Biodegradation Biocatalysis Cell imaging Protein analysis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2D06AD6AE589]
http://linked.open...i/riv/nazevZdroje	Biotechnology Journal
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Czech Republic representation in the European Research Consortium for Informatics and Mathematics (ERCIM) Strukturně-funkční vztahy haloalkan dehalogenas Construction of a synthetic metabolic pathway for degradation of important environmental pollutant using protein and metabolic engineering CETOCOEN Specific ion effects for proteins in solutions and related biologically relevant systems.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Bidmanová, Šárka Chaloupková, Radka Damborský, Jiří Dvořák, Pavel Koudeláková, Táňa Pavelka, Antonín Prokop, Zbyněk
http://linked.open...ain/vavai/riv/wos	000312989500012
issn	1860-6768
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/biot.201100486
http://localhost/t...ganizacniJednotka	14310

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