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  • This review highlights the importance of gates in enzymes. The gates control substrate access to the active site and product release, restrict solvent access to specific protein regions, and synchronize processes occurring in distinct parts of the enzyme. Survey of 129 gates in 71 enzymes enabled a rigorous definition of gates and establishment of a new scheme for their classification. Gates were assigned to six distinct classes – wings, swinging doors, apertures, drawbridges, double drawbridges and shells. Presented are summary statistics describing the propensity of specific amino acid residues in particular gate classes. The proposed classification scheme provides guidance for the analysis and engineering of gates in biomolecular systems.
  • This review highlights the importance of gates in enzymes. The gates control substrate access to the active site and product release, restrict solvent access to specific protein regions, and synchronize processes occurring in distinct parts of the enzyme. Survey of 129 gates in 71 enzymes enabled a rigorous definition of gates and establishment of a new scheme for their classification. Gates were assigned to six distinct classes – wings, swinging doors, apertures, drawbridges, double drawbridges and shells. Presented are summary statistics describing the propensity of specific amino acid residues in particular gate classes. The proposed classification scheme provides guidance for the analysis and engineering of gates in biomolecular systems. (en)
Title
  • Gates of Enzymes.
  • Gates of Enzymes. (en)
skos:prefLabel
  • Gates of Enzymes.
  • Gates of Enzymes. (en)
skos:notation
  • RIV/00216224:14310/13:00065828!RIV14-MSM-14310___
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  • P(ED0001/01/01), P(ED1.100/02/0123), P(GAP207/12/0775), P(GAP503/12/0572), P(IAA401630901)
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  • 8
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  • 76204
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  • RIV/00216224:14310/13:00065828
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  • haloalkane dehalogenases (en)
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  • US - Spojené státy americké
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  • [DD69950FD755]
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  • Chemical Reviews
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  • 113
http://linked.open...iv/tvurceVysledku
  • Brezovský, Jan
  • Damborský, Jiří
  • Gora, Artur Wiktor
http://linked.open...ain/vavai/riv/wos
  • 000323301200006
issn
  • 0009-2665
number of pages
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  • 10.1021/cr300384w
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  • 14310
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