About: Low-Glucose Conditions of Tumor Microenvironment enhance cytotoxicity of tetrathiomolybdate to neuroblastoma cells

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About: Low-Glucose Conditions of Tumor Microenvironment enhance cytotoxicity of tetrathiomolybdate to neuroblastoma cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Growth of tumor cells depends on sufficient supply of fermentable substrate, such as glucose. This provokes development of new anti-cancer therapies based on dietary restrictions. However, some tumor cells can lower their glucose dependency and activate processes of ATP formation/saving to retain viability even in limited glucose supply. In addition, tumor cells often loose sensitivity to many conventional anti-cancer drugs in the low-glucose conditions. Thus, development of the drugs effectively killing the tumor cells in nutrient-limited conditions is necessary. In this study, we show an enhanced cytotoxicity of tetrathiomolybdate, the drug exhibiting anti-angiogenic and tumor-suppressing effects, to neuroblastoma SH-SY5Y and SK-N-BE(2) cells in the low-glucose conditions. This preference results from the tetrathiomolybdate-induced upregulation of cell dependency on glucose. Growth of tumor cells depends on sufficient supply of fermentable substrate, such as glucose. This provokes development of new anti-cancer therapies based on dietary restrictions. However, some tumor cells can lower their glucose dependency and activate processes of ATP formation/saving to retain viability even in limited glucose supply. In addition, tumor cells often loose sensitivity to many conventional anti-cancer drugs in the low-glucose conditions. Thus, development of the drugs effectively killing the tumor cells in nutrient-limited conditions is necessary. In this study, we show an enhanced cytotoxicity of tetrathiomolybdate, the drug exhibiting anti-angiogenic and tumor-suppressing effects, to neuroblastoma SH-SY5Y and SK-N-BE(2) cells in the low-glucose conditions. This preference results from the tetrathiomolybdate-induced upregulation of cell dependency on glucose. (en)
Title	Low-Glucose Conditions of Tumor Microenvironment enhance cytotoxicity of tetrathiomolybdate to neuroblastoma cells Low-Glucose Conditions of Tumor Microenvironment enhance cytotoxicity of tetrathiomolybdate to neuroblastoma cells (en)
skos:prefLabel	Low-Glucose Conditions of Tumor Microenvironment enhance cytotoxicity of tetrathiomolybdate to neuroblastoma cells Low-Glucose Conditions of Tumor Microenvironment enhance cytotoxicity of tetrathiomolybdate to neuroblastoma cells (en)
skos:notation	RIV/00216224:14310/13:00065615!RIV14-MZ0-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123), P(GA301/09/1115), P(NT13441)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Navrátilová, Jarmila Hankeová, Tereza Beneš, Petr Šmarda, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	85504
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/13:00065615
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tetrathiomolybdate; neuroblastoma; glucose starvation; apoptosis; cancer therapy (en)
http://linked.open.../riv/klicoveSlovo	glucose starvation tetrathiomolybdate apoptosis neuroblastoma cancer therapy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[62ED9C8E2368]
http://linked.open...i/riv/nazevZdroje	Nutrition and Cancer
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of c-Myb and Cox-2 proteins in colon carcinogenesis Myb Protein Family Expression in Colorectal Adenocarcinoma and its Correlation to Metastatic Potential St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	65
http://linked.open...iv/tvurceVysledku	Beneš, Petr Šmarda, Jan Hankeová, Tereza Navrátilová, Jarmila
http://linked.open...ain/vavai/riv/wos	000321887700010
issn	0163-5581
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1080/01635581.2013.789118
http://localhost/t...ganizacniJednotka	14310

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