About: Specific conditions of tumor microenvironment enhance cytotoxicity of disulfiram, tetrathiomolybdate and wedelolactone to breast cancer and neuroblastoma cells     Goto   Sponge   NotDistinct   Permalink

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  • Our study was designed to analyze the effects of hypoxia, acidosis, and limited glucose supply to cytotoxicity of disulfiram, tetrathiomolybdate and wedelolactone to breast cancer and neuroblastoma cells. We found that cytotoxicity of these drugs can be strongly enhanced by manipulating tissue culture conditions that simulate the character of tumor microenvironment.
  • Our study was designed to analyze the effects of hypoxia, acidosis, and limited glucose supply to cytotoxicity of disulfiram, tetrathiomolybdate and wedelolactone to breast cancer and neuroblastoma cells. We found that cytotoxicity of these drugs can be strongly enhanced by manipulating tissue culture conditions that simulate the character of tumor microenvironment. (en)
Title
  • Specific conditions of tumor microenvironment enhance cytotoxicity of disulfiram, tetrathiomolybdate and wedelolactone to breast cancer and neuroblastoma cells
  • Specific conditions of tumor microenvironment enhance cytotoxicity of disulfiram, tetrathiomolybdate and wedelolactone to breast cancer and neuroblastoma cells (en)
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  • Specific conditions of tumor microenvironment enhance cytotoxicity of disulfiram, tetrathiomolybdate and wedelolactone to breast cancer and neuroblastoma cells
  • Specific conditions of tumor microenvironment enhance cytotoxicity of disulfiram, tetrathiomolybdate and wedelolactone to breast cancer and neuroblastoma cells (en)
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  • RIV/00216224:14310/13:00065600!RIV14-MZ0-14310___
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  • RIV/00216224:14310/13:00065600
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  • disulfiram; breast cancer; wedelolactone; tumor microenvironment; cytotoxicity (en)
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  • [79A4807AD8C3]
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  • Beneš, Petr
  • Knopfová, Lucia
  • Šmarda, Jan
  • Hankeová, Tereza
  • Navrátilová, Jarmila
  • Nehybová, Tereza
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  • 14310
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