About: Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis     Goto   Sponge   NotDistinct   Permalink

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Description
  • Aortic valve stenosis (AoS) is the most common acquired valvular disorder found in developed countries, being present in 2% to 7% of adults over the age of 65 [1], [2] and [3]. Calcified AoS is a chronic progressive disease. The pathomechanisms leading to valve degeneration remain unknown. Valve disease shares many features with atherosclerosis. Platelet activation is an important constituent of the atherosclerotic process [4] and [5]. The study focused on two platelet-derived chemokines, which bridge three important components of atherogenesis: platelet activation, inflammation, and generation of atheroma. The study group was comprised of 124 consecutive patients being considered for aortic valve replacement for symptomatic degenerative trileaflet valvular AoS, and were undergoing cardiac catheterization in the Cardiocentre [6]. The exclusion criterion was the presence of an additional hemodynamically significant valve disease.
  • Aortic valve stenosis (AoS) is the most common acquired valvular disorder found in developed countries, being present in 2% to 7% of adults over the age of 65 [1], [2] and [3]. Calcified AoS is a chronic progressive disease. The pathomechanisms leading to valve degeneration remain unknown. Valve disease shares many features with atherosclerosis. Platelet activation is an important constituent of the atherosclerotic process [4] and [5]. The study focused on two platelet-derived chemokines, which bridge three important components of atherogenesis: platelet activation, inflammation, and generation of atheroma. The study group was comprised of 124 consecutive patients being considered for aortic valve replacement for symptomatic degenerative trileaflet valvular AoS, and were undergoing cardiac catheterization in the Cardiocentre [6]. The exclusion criterion was the presence of an additional hemodynamically significant valve disease. (en)
Title
  • Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis
  • Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis (en)
skos:prefLabel
  • Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis
  • Platelet-derived chemokines, PF-4 and RANTES, are significantly increased in hemodynamically significant degenerative aortic stenosis (en)
skos:notation
  • RIV/00216224:14310/11:00061085!RIV13-MSM-14310___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • R, S, Z(MSM0021620817)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 220550
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/11:00061085
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Degenerative aortic stenosis; Platelet-derived chemokines; Platelet factor-4 (CXCL4); RANTES (CCL5) (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • IE - Irsko
http://linked.open...ontrolniKodProRIV
  • [A78727CDF8C0]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Cardiology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 152
http://linked.open...iv/tvurceVysledku
  • Katina, Stanislav
  • Karpisek, M.
  • Hrabakova, H.
  • Kocka, V.
  • Motovska, Z.
  • Odvodyova, D.
  • Simkova, I.
  • Widimsky, P.
http://linked.open...ain/vavai/riv/wos
  • 000296540800037
http://linked.open...n/vavai/riv/zamer
issn
  • 0167-5273
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.ijcard.2011.08.021
http://localhost/t...ganizacniJednotka
  • 14310
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