About: The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro.

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About: The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study investigated PAHs and N-PAHs interference with retinoid signaling in vitro by modulating all-trans retinoic acid (ATRA) mediated response in a reporter gene assay using P19/A15 cell line. Further, effects on pluripotency and differentiation processes were evaluated by measuring octamer-4 (Oct-4), an important pluripotency marker and master differentiation factor. Our results further extend the knowledge of PAH and N-PAH in vitro effects and indicate that these environmental toxicants may have influence on differentiation process and embryonic development by interfering with ATRA signaling and by modulating levels of Oct-4. This study investigated PAHs and N-PAHs interference with retinoid signaling in vitro by modulating all-trans retinoic acid (ATRA) mediated response in a reporter gene assay using P19/A15 cell line. Further, effects on pluripotency and differentiation processes were evaluated by measuring octamer-4 (Oct-4), an important pluripotency marker and master differentiation factor. Our results further extend the knowledge of PAH and N-PAH in vitro effects and indicate that these environmental toxicants may have influence on differentiation process and embryonic development by interfering with ATRA signaling and by modulating levels of Oct-4. (en)
Title	The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro. The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro. (en)
skos:prefLabel	The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro. The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro. (en)
skos:notation	RIV/00216224:14310/11:00053414!RIV12-MSM-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(2B08036), P(ED0001/01/01), S, Z(MSM0021622412)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Beníšek, Martin Kubincová, Petra Bláha, Luděk Hilscherová, Klára
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	196661
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/11:00053414
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	retinoids; differentiation; Oct-4; PAHs; N-PAHs (en)
http://linked.open.../riv/klicoveSlovo	PAHs retinoids N-PAHs Oct-4 differentiation
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[6EE28084D683]
http://linked.open...i/riv/nazevZdroje	Toxicology Letters
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	CETOCOEN New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	200
http://linked.open...iv/tvurceVysledku	Bláha, Luděk Hilscherová, Klára Beníšek, Martin Kubincová, Petra
http://linked.open...ain/vavai/riv/wos	000287216900006
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
issn	0378-4274
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.toxlet.2010.11.011
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro. The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro.

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