About: Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.     Goto   Sponge   NotDistinct   Permalink

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Description
  • The synthesis and hit-to-lead SAR development of a pyrazolo[1,5-a]pyrimidine hit 4 is described leading to a series of potent, selective CHK1 inhibitors such as compound 17r. In the Letter, the further utility of the pyrazolo[1,5-a]pyrimidine template for the development of potent, selective kinase inhibitors is detailed.
  • The synthesis and hit-to-lead SAR development of a pyrazolo[1,5-a]pyrimidine hit 4 is described leading to a series of potent, selective CHK1 inhibitors such as compound 17r. In the Letter, the further utility of the pyrazolo[1,5-a]pyrimidine template for the development of potent, selective kinase inhibitors is detailed. (en)
Title
  • Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.
  • Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1. (en)
skos:prefLabel
  • Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.
  • Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1. (en)
skos:notation
  • RIV/00216224:14310/11:00051795!RIV12-MSM-14310___
http://linked.open...avai/predkladatel
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  • N
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  • 1
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  • 194791
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  • RIV/00216224:14310/11:00051795
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Kinase CHK1 Pyrazolo[1 5-a]pyrimidine Template (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [7CEC9DDAF827]
http://linked.open...i/riv/nazevZdroje
  • Bioorganic & Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 21
http://linked.open...iv/tvurceVysledku
  • Alvarez, Carmen
  • Davis, Nicole
  • Duca, Jose
  • Dwyer, Michael
  • Fischmann, Thierry
  • Guzi, Timothy
  • Keertikar, Kerry
  • Labroli, Marc
  • Madison, Vincent
  • Parry, David
  • Paruch, Kamil
  • Poker, Cory
  • Rossman, Randall
  • Seghezzi, Wolfgang
  • Wiswell, Derek
issn
  • 0960-894X
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  • 14310
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