About: Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction

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About: Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aim The purpose of this study was to asses the impact of haemostatic and platelet receptor gene polymorphisms as an inherited risk factor for premature onset of myocardial infarction (MI). Methods Polymorphisms of platelet receptors - GP Ia (807C>T, rs1126643), GP VI (13254T>C, rs1613662), GP IIIa (HPA-1, rs5918), PAR -1 (IVS -14A>T; rs168753), P2Y12 (34C>T, rs6785930 and H1/H2 haplotype, rs2046934), and genetic variations of the gene coding for cyclooxygenase-1 (COX-1) ( -842A>G, rs10306114 and 50C>T, rs3842787) were investigated. Mutations in the genes coding for coagulation factor V (Q506R (Leiden) mutation, rs6025) and factor II (prothrombin G20210A, rs1799963) were also determined. The prevalence of gene polymorphisms was investigated in 105 consecutive patients with premature MI. This was compared with the same gene polymorphism prevalence in a group of 132 patients in which coronary artery disease had been excluded. Aim The purpose of this study was to asses the impact of haemostatic and platelet receptor gene polymorphisms as an inherited risk factor for premature onset of myocardial infarction (MI). Methods Polymorphisms of platelet receptors - GP Ia (807C>T, rs1126643), GP VI (13254T>C, rs1613662), GP IIIa (HPA-1, rs5918), PAR -1 (IVS -14A>T; rs168753), P2Y12 (34C>T, rs6785930 and H1/H2 haplotype, rs2046934), and genetic variations of the gene coding for cyclooxygenase-1 (COX-1) ( -842A>G, rs10306114 and 50C>T, rs3842787) were investigated. Mutations in the genes coding for coagulation factor V (Q506R (Leiden) mutation, rs6025) and factor II (prothrombin G20210A, rs1799963) were also determined. The prevalence of gene polymorphisms was investigated in 105 consecutive patients with premature MI. This was compared with the same gene polymorphism prevalence in a group of 132 patients in which coronary artery disease had been excluded. (en)
Title	Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction (en)
skos:prefLabel	Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction (en)
skos:notation	RIV/00216224:14310/10:00061091!RIV13-MSM-14310___
http://linked.open...avai/riv/aktivita	I R Z
http://linked.open...avai/riv/aktivity	I, R, Z(MSM0021620817), Z(MZ0VFN2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Katina, Stanislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	279151
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00061091
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	myocardial infarction; risk factor; platelet glycoprotein (en)
http://linked.open.../riv/klicoveSlovo	myocardial infarction risk factor platelet glycoprotein
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[A9E493E691AD]
http://linked.open...i/riv/nazevZdroje	Thrombosis Research
http://linked.open...in/vavai/riv/obor	BB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	125
http://linked.open...iv/tvurceVysledku	Katina, Stanislav Widimský, P. Motovska, Z. Odvodyova, D. Petr, R. Kvasnicka, J. Bobciková, P. Hajková, J. Osmancik, P.
http://linked.open...ain/vavai/riv/wos	000274937400028
http://linked.open...n/vavai/riv/zamer	Invasive Approaches to Rescue and Regenerate Jeopardized Myocardium Diagnosis and treatment of inherited disorders II
issn	0049-3848
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.thromres.2009.09.002
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction

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