About: Interference of some environmental contaminants with retinoid signaling in vitro

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Retinoids are dietary hormones important during proliferation, differentiation and apoptosis.They act mainly through nuclear receptors for retinoic acid, RARs and RXRs. Disruption of these signaling pathways can lead to several adverse effects especially during embryonic development. Using pluripotent P19/A15 cell we tested whether some polycyclic aromatic hydrocarbons (PAHs), their N-heterocyclic analogs and some personal care products(UV filters, parabens) can interfere with retinoid signaling. Studied compounds were tested for direct activation of RAR/RXR signaling pathway, but also modulation of the response of natural ligand all-trans retinoic acid (ATRA) by studied compounds was tested. No direct activation was found for studied PAHs and N-PAHs, however, some of these compounds modulated the response of ATRA. Downregulation of the response was observed mostly for 2 and 3-ring N-PAHs, while 4 and 5-ring PAHs and N-PAHs mostly up-regulated the response of ATRA. Retinoids are dietary hormones important during proliferation, differentiation and apoptosis.They act mainly through nuclear receptors for retinoic acid, RARs and RXRs. Disruption of these signaling pathways can lead to several adverse effects especially during embryonic development. Using pluripotent P19/A15 cell we tested whether some polycyclic aromatic hydrocarbons (PAHs), their N-heterocyclic analogs and some personal care products(UV filters, parabens) can interfere with retinoid signaling. Studied compounds were tested for direct activation of RAR/RXR signaling pathway, but also modulation of the response of natural ligand all-trans retinoic acid (ATRA) by studied compounds was tested. No direct activation was found for studied PAHs and N-PAHs, however, some of these compounds modulated the response of ATRA. Downregulation of the response was observed mostly for 2 and 3-ring N-PAHs, while 4 and 5-ring PAHs and N-PAHs mostly up-regulated the response of ATRA. (en)
Title	Interference of some environmental contaminants with retinoid signaling in vitro Interference of some environmental contaminants with retinoid signaling in vitro (en)
skos:prefLabel	Interference of some environmental contaminants with retinoid signaling in vitro Interference of some environmental contaminants with retinoid signaling in vitro (en)
skos:notation	RIV/00216224:14310/10:00046581!RIV11-MSM-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(2B08036)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Richterová, Martina Beníšek, Martin Kubincová, Petra Hilscherová, Klára
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	264482
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00046581
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	retinoids; personal care products; PAHs; N-PAHs (en)
http://linked.open.../riv/klicoveSlovo	PAHs retinoids N-PAHs personal care products
http://linked.open...ontrolniKodProRIV	[6E3D045438EC]
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R.
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Hilscherová, Klára Beníšek, Martin Kubincová, Petra Richterová, Martina
http://localhost/t...ganizacniJednotka	14310

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