About: Disruption of retinoid signalling and differentiation process by PAHs and N-PAHs in vitro

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About: Disruption of retinoid signalling and differentiation process by PAHs and N-PAHs in vitro Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Polycyclic aromatic hydrocarbons (PAHs) are similar to their N-heterocyclic analogs (N-PAHs) important and widespread environmental contaminants generated especially by the incomplete combustion of organic materials. Many of them are known carcinogens, mutagens and teratogens. Teratogenicity of PAHs and N-PAHs could be caused by disruption of retinoid signaling by these compounds, as retinoid levels are crucial for differentiation process and normal embryonic development. In this study the interference of PAHs and N-PAHs with retinoid signaling system was tested using P19/A15 cell line (Approximately one half of tested compounds downregulated RA activity after 6h exposure with lower or no downregulation after 24 h. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Polycyclic aromatic hydrocarbons (PAHs) are similar to their N-heterocyclic analogs (N-PAHs) important and widespread environmental contaminants generated especially by the incomplete combustion of organic materials. Many of them are known carcinogens, mutagens and teratogens. Teratogenicity of PAHs and N-PAHs could be caused by disruption of retinoid signaling by these compounds, as retinoid levels are crucial for differentiation process and normal embryonic development. In this study the interference of PAHs and N-PAHs with retinoid signaling system was tested using P19/A15 cell line (Approximately one half of tested compounds downregulated RA activity after 6h exposure with lower or no downregulation after 24 h. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. (en)
Title	Disruption of retinoid signalling and differentiation process by PAHs and N-PAHs in vitro Disruption of retinoid signalling and differentiation process by PAHs and N-PAHs in vitro (en)
skos:prefLabel	Disruption of retinoid signalling and differentiation process by PAHs and N-PAHs in vitro Disruption of retinoid signalling and differentiation process by PAHs and N-PAHs in vitro (en)
skos:notation	RIV/00216224:14310/10:00046568!RIV11-MSM-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(2B08036)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Beníšek, Martin Kubincová, Petra Bláha, Luděk Hilscherová, Klára
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	254673
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00046568
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	retinoids; differentiation; PAHs; N-PAHs (en)
http://linked.open.../riv/klicoveSlovo	PAHs retinoids N-PAHs differentiation
http://linked.open...ontrolniKodProRIV	[26A70919CE2B]
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R.
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Bláha, Luděk Hilscherová, Klára Beníšek, Martin Kubincová, Petra
http://localhost/t...ganizacniJednotka	14310

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