About: GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY     Goto   Sponge   NotDistinct   Permalink

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Description
  • Glyoxyl analogs of indole phytoalexins brassinin, 1-methoxybrassinin, brassitin, 1-methoxybrassitin and 1-methoxybrassenin B were prepared, using (1H-indol-3-yl)-, (1-methoxyindol- 3-yl)- and [1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)indol-3-yl]glyoxyl chlorides as starting compounds. Synthesized products were examined for their antiproliferative activity against human cancer cell lines Jurkat (T-cell acute lymphoblastic leukemia), MCF-7 (breast adenocarcinoma, estrogen receptor-positive), MDA-MB-231 (breast adenocarcinoma, estrogen receptor-negative), HeLa (cervical adenocarcinoma), CCRF-CEM cell line (T-cell acute lymphoblastic leukemia) and A-549 cell line (lung adenocarcinoma), and their activity compared with natural phytoalexins and corresponding (1H-indol-3-yl)acetic acid derivatives. The highest potency with IC50 3.3-66.1 mímol l-1 was found for glyoxyl analogs of 1-methoxybrassenin B.
  • Glyoxyl analogs of indole phytoalexins brassinin, 1-methoxybrassinin, brassitin, 1-methoxybrassitin and 1-methoxybrassenin B were prepared, using (1H-indol-3-yl)-, (1-methoxyindol- 3-yl)- and [1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)indol-3-yl]glyoxyl chlorides as starting compounds. Synthesized products were examined for their antiproliferative activity against human cancer cell lines Jurkat (T-cell acute lymphoblastic leukemia), MCF-7 (breast adenocarcinoma, estrogen receptor-positive), MDA-MB-231 (breast adenocarcinoma, estrogen receptor-negative), HeLa (cervical adenocarcinoma), CCRF-CEM cell line (T-cell acute lymphoblastic leukemia) and A-549 cell line (lung adenocarcinoma), and their activity compared with natural phytoalexins and corresponding (1H-indol-3-yl)acetic acid derivatives. The highest potency with IC50 3.3-66.1 mímol l-1 was found for glyoxyl analogs of 1-methoxybrassenin B. (en)
Title
  • GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY
  • GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY (en)
skos:prefLabel
  • GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY
  • GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY (en)
skos:notation
  • RIV/00216224:14310/10:00044943!RIV11-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 260857
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/10:00044943
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Heterocycles; Indoles; Natural products; Phytoalexins; Glyoxylindoles (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [384DB899CC29]
http://linked.open...i/riv/nazevZdroje
  • Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 75
http://linked.open...iv/tvurceVysledku
  • Pazdera, Pavel
  • Mezencev, Roman
  • Pilátová, Martina
  • Kutschy, Peter
  • Hromjáková, Tatiana
  • Mojžiš, Ján
  • Repovská, Mária
  • Sýkora, Andrej
  • Čurillová, Zuzana
http://linked.open...ain/vavai/riv/wos
  • 2010048
issn
  • 0010-0765
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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