About: Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L.

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About: Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We posed the hypothesis that eicosanoids also mediate antioxidant enzymatic defense reactions to pro-oxidant challenge. To test this idea, we reared first-instar larvae of Galleria mellonella (L.) with the lypoxygenase inhibitor, esculetin, the phospholipase A2 inhibitor,dexamethasone and the dual inhibitor of cyclooxygenase and lipoxygenase, phenidone to seventh-instars. Newly ecdysed seventh-instars were then fed on artificial diet containing xanthotoxin (XA) for 2 days. Treating seventh-instar larvae of G. mellonella with XA induced lipid peroxidation and protein carbonylation as evident from the increased content of malondialdehyde (MDA) and protein carbonyls respectively, and antioxidative enzymatic response in a dose-dependent manner. Relative to control, eicosanoid biosynthesis inhibitors also resulted in impaired MDA content and antioxidant enzyme activities. We infer from these findings that eicosanoids mediate insect antioxidant enzymatic responses to dietary pro-oxidants. We posed the hypothesis that eicosanoids also mediate antioxidant enzymatic defense reactions to pro-oxidant challenge. To test this idea, we reared first-instar larvae of Galleria mellonella (L.) with the lypoxygenase inhibitor, esculetin, the phospholipase A2 inhibitor,dexamethasone and the dual inhibitor of cyclooxygenase and lipoxygenase, phenidone to seventh-instars. Newly ecdysed seventh-instars were then fed on artificial diet containing xanthotoxin (XA) for 2 days. Treating seventh-instar larvae of G. mellonella with XA induced lipid peroxidation and protein carbonylation as evident from the increased content of malondialdehyde (MDA) and protein carbonyls respectively, and antioxidative enzymatic response in a dose-dependent manner. Relative to control, eicosanoid biosynthesis inhibitors also resulted in impaired MDA content and antioxidant enzyme activities. We infer from these findings that eicosanoids mediate insect antioxidant enzymatic responses to dietary pro-oxidants. (en)
Title	Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L. Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L. (en)
skos:prefLabel	Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L. Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L. (en)
skos:notation	RIV/00216224:14310/10:00043258!RIV11-MSM-14310___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hyršl, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	256430
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00043258
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Eicosanoids; Galleria mellonella; antioxidant enzymes; oxidative stress; pro-oxidant (en)
http://linked.open.../riv/klicoveSlovo	Galleria mellonella Eicosanoids antioxidant enzymes oxidative stress pro-oxidant
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7543E69CE200]
http://linked.open...i/riv/nazevZdroje	Comparative Biochemistry and Physiology A - Molecular & Integrative Physiology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	156
http://linked.open...iv/tvurceVysledku	Hyršl, Pavel Büyükgüzel, Ender Büyükgüzel, Kemal
http://linked.open...ain/vavai/riv/wos	000277748500003
issn	1095-6433
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L. Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L. Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L.

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