About: Electrochemical biosensor for investigation of anticancer drugs interactions (doxorubicin and ellipticine) with DNA

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The mechanisms of action of chemotherapeutics are different, but very often interfere with processes of cell division and can bind onto DNA. The aim of this work was to investigate interactions of antitumour drugs (ellipticine and doxorubicin) with DNA. For these purposes our experiments the screen-printed nanotube carbon electrodes were used. DNA gives oxidation signals for all bases (adenine, cytosine, guanine and thymine). We introduced various ellipticine, doxorubicin and ethidium bromide concentrations to DNA on carbon electrodes fabricated by us and measured the changes in the height of nucleic acid bases signals. In the voltammograms measured the changes associated with the interactions of the target compounds with DNA were evident. The height of DNA signals decreased with increasing ellipticine, doxorubicin and ethidium bromide concentrations. The decrease can be related to changes of DNA structure caused by the intercalation. The mechanisms of action of chemotherapeutics are different, but very often interfere with processes of cell division and can bind onto DNA. The aim of this work was to investigate interactions of antitumour drugs (ellipticine and doxorubicin) with DNA. For these purposes our experiments the screen-printed nanotube carbon electrodes were used. DNA gives oxidation signals for all bases (adenine, cytosine, guanine and thymine). We introduced various ellipticine, doxorubicin and ethidium bromide concentrations to DNA on carbon electrodes fabricated by us and measured the changes in the height of nucleic acid bases signals. In the voltammograms measured the changes associated with the interactions of the target compounds with DNA were evident. The height of DNA signals decreased with increasing ellipticine, doxorubicin and ethidium bromide concentrations. The decrease can be related to changes of DNA structure caused by the intercalation. (en)
Title	Electrochemical biosensor for investigation of anticancer drugs interactions (doxorubicin and ellipticine) with DNA Electrochemical biosensor for investigation of anticancer drugs interactions (doxorubicin and ellipticine) with DNA (en)
skos:prefLabel	Electrochemical biosensor for investigation of anticancer drugs interactions (doxorubicin and ellipticine) with DNA Electrochemical biosensor for investigation of anticancer drugs interactions (doxorubicin and ellipticine) with DNA (en)
skos:notation	RIV/00216224:14310/09:00063549!RIV13-MSM-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA102/08/1546), P(KAN208130801), P(LC06035)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Trnková, Libuše
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	256697
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00063549
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NEUROBLASTOMA-CELL LINES; ADDUCT FORMATION; NANOPARTICLES; CANCER; DEOXYGUANOSINE; MICROSOMES; RESISTANCE; OXIDATION; UPDATE; MODEL (en)
http://linked.open.../riv/klicoveSlovo	CANCER MODEL ADDUCT FORMATION DEOXYGUANOSINE MICROSOMES NEUROBLASTOMA-CELL LINES UPDATE RESISTANCE OXIDATION NANOPARTICLES
http://linked.open...ontrolniKodProRIV	[BECCAE6BE63D]
http://linked.open...v/mistoKonaniAkce	Nový Zéland
http://linked.open...i/riv/mistoVydani	USA
http://linked.open...i/riv/nazevZdroje	2009 IEEE SENSORS
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED) Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine. Miniaturized intelligent systems and nanostructured elektrodes for chemical, biological, and pharmaceutical applications (NANIMEL)
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Eckschlager, Tomáš Hubálek, Jaromír Húska, Dalibor Kizek, René Trnková, Libuše Stiborova, Marie
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open...ain/vavai/riv/wos	000279891700264
http://linked.open.../riv/zahajeniAkce	2009-01-01 (xsd:date)
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1109/ICSENS.2009.5398361
http://purl.org/ne...btex#hasPublisher	IEEE
https://schema.org/isbn	9781424445486
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Electrochemical biosensor for investigation of anticancer drugs interactions (doxorubicin and ellipticine) with DNA

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