About: MDM2 SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk

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About: MDM2 SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	SNP309 polymorphism (T-G) at the promoter region of MDM2 has been reported to cause increased binding affinity of transcriptional activator Sp1 followed by increased MDM2 both in mRNA and protein level. This model was proposed in vitro in the small panel of cell lines that indicated an on average 8-fold higher level of MDM2 mRNA in cells bearing the GG genotype. No significant difference was observed in the G allele incidence in breast cancer specimens compared to 149 noncancer controls. Furthermore, no statistically significant association of the G allele frequencies and p53 and MDM2 protein expression levels was observed. Our data clearly show neither association between SNP309 and cancer risk, nor the responsibility of G allele for increased MDM2 or decreased of p53 protein levels in human primary breast tumors. SNP309 polymorphism (T-G) at the promoter region of MDM2 has been reported to cause increased binding affinity of transcriptional activator Sp1 followed by increased MDM2 both in mRNA and protein level. This model was proposed in vitro in the small panel of cell lines that indicated an on average 8-fold higher level of MDM2 mRNA in cells bearing the GG genotype. No significant difference was observed in the G allele incidence in breast cancer specimens compared to 149 noncancer controls. Furthermore, no statistically significant association of the G allele frequencies and p53 and MDM2 protein expression levels was observed. Our data clearly show neither association between SNP309 and cancer risk, nor the responsibility of G allele for increased MDM2 or decreased of p53 protein levels in human primary breast tumors. (en)
Title	MDM2 SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk MDM2 SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk (en)
skos:prefLabel	MDM2 SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk MDM2 SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk (en)
skos:notation	RIV/00216224:14310/08:00039782!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(NR8338), V
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hrstka, Roman Müller, Petr Vojtěšek, Bořivoj Krekáč, Daniel Nenutil, Rudolf Hrazdilová, Kristýna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	378074
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00039782
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MDM2; SNP309; p53 (en)
http://linked.open.../riv/klicoveSlovo	p53 MDM2 SNP309
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[30F57A4AF315]
http://linked.open...i/riv/nazevZdroje	Oncology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional analysis of the p53-dependent pathways in breast cancer: Integration of genomic and proteomic approaches using DNA-macroarray and SELDI-TOF mass spectrometry techniques
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Hrstka, Roman Vojtěšek, Bořivoj Müller, Petr Nenutil, Rudolf Knoflíčková, Dana Hrazdilová, Kristýna Krekáč, Daniel
http://linked.open...ain/vavai/riv/wos	000256752300013
issn	0030-2414
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	MDM2 SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk MDM2 SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk MDM2 SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk MDM2 SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk

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