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  • OBJECTIVES: The objective was to make a contribution to deepening the knowledge of the etiopathogenesis of ADHD. DESIGN: in an association study design, an analysis of polymorphisms of selected genes was conducted in 119 hyperkinetic boys and a control group of boys, aged 7 to 13. Furthermore several psychologically determined subgroups were identified. A connection between psychological functions (endophenotypes) and genes were looked for. RESULTS: There was a statistically significant difference found in allelic and genotype frequencies of the TaqI A polymorphism of the DRD2 gene. The frequency of the allele A1 in hyperkinetic boys and the control subjects was 0.26 and 0.15, respectively (0.003). A statistically significant occurrence of atypical genotypes (8/10, 7/10 and 10/11) of the DAT1 gene was also found in hyperkinetic boys and a connection between the M235 polymorphi sm of the angiotensinogene gene and the positive family history of psychiatric illness was found in probands (p=0.031).
  • OBJECTIVES: The objective was to make a contribution to deepening the knowledge of the etiopathogenesis of ADHD. DESIGN: in an association study design, an analysis of polymorphisms of selected genes was conducted in 119 hyperkinetic boys and a control group of boys, aged 7 to 13. Furthermore several psychologically determined subgroups were identified. A connection between psychological functions (endophenotypes) and genes were looked for. RESULTS: There was a statistically significant difference found in allelic and genotype frequencies of the TaqI A polymorphism of the DRD2 gene. The frequency of the allele A1 in hyperkinetic boys and the control subjects was 0.26 and 0.15, respectively (0.003). A statistically significant occurrence of atypical genotypes (8/10, 7/10 and 10/11) of the DAT1 gene was also found in hyperkinetic boys and a connection between the M235 polymorphi sm of the angiotensinogene gene and the positive family history of psychiatric illness was found in probands (p=0.031). (en)
Title
  • Clinical and molecular-genetic markers of ADHD in children
  • Clinical and molecular-genetic markers of ADHD in children (en)
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  • Clinical and molecular-genetic markers of ADHD in children
  • Clinical and molecular-genetic markers of ADHD in children (en)
skos:notation
  • RIV/00216224:14310/08:00028246!RIV10-MZ0-14310___
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  • P(NR9298)
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  • 3
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  • 360133
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  • RIV/00216224:14310/08:00028246
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  • molecular genetic study; ADHD; DRD2; DAT1; AGT; IL-6; TNF-alpha; BDNF (en)
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  • SE - Švédské království
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  • [ECF683DE7EAC]
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  • Neuroendocrinology Letters
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  • 29
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  • Drtílková, Ivana
  • Šerý, Omar
  • Theiner, Pavel
  • Žáčková, Markéta
  • Uhrová, Alena
  • Znojil, Vladimír
  • Balaštíková, Blanka
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  • 0172-780X
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  • 14310
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