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  • Humic substances (HS) are ubiquitous natural products of decomposition of dead organic matter. In our previous in vitro study, we have described interaction of HS with AhR5, which has been also confirmed in vivo6. In this contribution, we summarize our new findings on interaction of both AhR-active and -inactive HS with 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD). We have observed decrease of TCDD-caused AhR-mediated effect at very high amounts of both TCDD and AhR-active HS. On the other hand, AhR-mediated effect was rather additive at lower concentrations of both TCDD and AhR-active HS. The possible mechanisms are discussed.
  • Humic substances (HS) are ubiquitous natural products of decomposition of dead organic matter. In our previous in vitro study, we have described interaction of HS with AhR5, which has been also confirmed in vivo6. In this contribution, we summarize our new findings on interaction of both AhR-active and -inactive HS with 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD). We have observed decrease of TCDD-caused AhR-mediated effect at very high amounts of both TCDD and AhR-active HS. On the other hand, AhR-mediated effect was rather additive at lower concentrations of both TCDD and AhR-active HS. The possible mechanisms are discussed. (en)
Title
  • IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD
  • IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD (en)
skos:prefLabel
  • IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD
  • IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD (en)
skos:notation
  • RIV/00216224:14310/08:00025285!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP525/08/P464), S, Z(MSM0021622412)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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  • 371777
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/08:00025285
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • humic substances; Ah receptor; dioxin; interaction; agonist (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [F04A4D5DD5E9]
http://linked.open...in/vavai/riv/obor
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Hilscherová, Klára
  • Bittner, Michal
  • Giesy, John P.
http://linked.open...n/vavai/riv/zamer
http://localhost/t...ganizacniJednotka
  • 14310
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