About: Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution     Goto   Sponge   NotDistinct   Permalink

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Description
  • Fits in a pocket: The binding mode of epothilone A (EpoA) to tubulin is determined by NMR spectroscopy in aqueous solution. The results explain the existing structure-activity relationship data for epothilones with both native and mutant tubulins, and support the existence of a common pharmacophore for EpoA and paclitaxel.
  • Fits in a pocket: The binding mode of epothilone A (EpoA) to tubulin is determined by NMR spectroscopy in aqueous solution. The results explain the existing structure-activity relationship data for epothilones with both native and mutant tubulins, and support the existence of a common pharmacophore for EpoA and paclitaxel. (en)
Title
  • Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution
  • Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution (en)
skos:prefLabel
  • Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution
  • Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution (en)
skos:notation
  • RIV/00216224:14310/07:00032343!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 11
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 452847
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/07:00032343
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • epothilones; NMR spectroscopy; structure elucidation; structure-activity relationships; tubulins (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [8F663B3C7587]
http://linked.open...i/riv/nazevZdroje
  • Angewandte Chemie International Edition
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 46
http://linked.open...iv/tvurceVysledku
  • Kubíček, Karel
  • Carlomagno, Teresa
  • Meiler, Jens
  • Sanchez-Pedregal, Victor M
  • Blommers, Marcel J
  • Griesinger, Christian
  • Reese, Marcel
issn
  • 1433-7851
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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