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Description
| - Glioblastoma multiforme (GBM) is the most common as well as the most aggressive type of adult primary brain tumor of astrocytic origin. GBM is characterized by a high degree of intratumoral heterogeneity both in histomorphology and genetic changes. Nevertheless, trisomy/polysomy of chromosome 7, monosomy of chromosome 10, EGFR gene amplification and p53 deletion have been described as the typical genetic markers for tumor classification and prediction of possible response to therapy. Our work was based on detection of these four main genetic changes both in central and peripheral parts of the tumors to evaluate possible differences in the topological incidence of these genetic markers. Chromosomal abnormalities in tumor samples from a group of 21 patients surgically treated for GBM were characterized by means of the interphase-fluorescence in situ hybridization (I-FISH) technique using sets of centromere and locus-specific DNA probes.
- Glioblastoma multiforme (GBM) is the most common as well as the most aggressive type of adult primary brain tumor of astrocytic origin. GBM is characterized by a high degree of intratumoral heterogeneity both in histomorphology and genetic changes. Nevertheless, trisomy/polysomy of chromosome 7, monosomy of chromosome 10, EGFR gene amplification and p53 deletion have been described as the typical genetic markers for tumor classification and prediction of possible response to therapy. Our work was based on detection of these four main genetic changes both in central and peripheral parts of the tumors to evaluate possible differences in the topological incidence of these genetic markers. Chromosomal abnormalities in tumor samples from a group of 21 patients surgically treated for GBM were characterized by means of the interphase-fluorescence in situ hybridization (I-FISH) technique using sets of centromere and locus-specific DNA probes. (en)
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Title
| - Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology
- Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology (en)
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skos:prefLabel
| - Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology
- Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology (en)
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skos:notation
| - RIV/00216224:14310/07:00022094!RIV10-MSM-14310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(OC B19.001), Z(MSM0021622415)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/07:00022094
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - glioblastoma multiforme; molecular cytogenetics; FISH; array-CGH (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Jarošová, Marie
- Kuglík, Petr
- Veselská, Renata
- Vranová, Vladimíra
- Cejpek, Pavel
- Nečesalová, Eva
- Pešáková, Martina
- Relichová, Jiřina
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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