About: Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization

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About: Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Comparative genomic hybridization (CGH) is a molecular cytogenetic technique that allows genome-wide analysis of DNA sequence copy number differences. We have applied conventional CGH and recently developed high resolution CGH (HR-CGH) to tumour samples from 18 patients with glioblastoma multiforme (GBM) to compare the sensitivity of CGH and HR-CGH in the screening of chromosomal abnormalities. The abnormalities were studied in topologically different central and peripheral tumour parts. A total of 78 different changes were observed using CGH (0-16 per tumour, median 3.5) and 154 different changes using HR-CGH (0-21 per tumour, median 6). Using HR-CGH, losses were more frequent than gains. The representation of the most prominent changes revealed by both methods was similar and was comprised of the amplification of 7q12-13 and 12q12-q15, the gain of 7, 3q and 19 and the loss of 10, 9p, and 13q. Comparative genomic hybridization (CGH) is a molecular cytogenetic technique that allows genome-wide analysis of DNA sequence copy number differences. We have applied conventional CGH and recently developed high resolution CGH (HR-CGH) to tumour samples from 18 patients with glioblastoma multiforme (GBM) to compare the sensitivity of CGH and HR-CGH in the screening of chromosomal abnormalities. The abnormalities were studied in topologically different central and peripheral tumour parts. A total of 78 different changes were observed using CGH (0-16 per tumour, median 3.5) and 154 different changes using HR-CGH (0-21 per tumour, median 6). Using HR-CGH, losses were more frequent than gains. The representation of the most prominent changes revealed by both methods was similar and was comprised of the amplification of 7q12-13 and 12q12-q15, the gain of 7, 3q and 19 and the loss of 10, 9p, and 13q. (en)
Title	Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization (en)
skos:prefLabel	Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization (en)
skos:notation	RIV/00216224:14310/07:00021808!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(OC B19.001), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Veselská, Renata Vranová, Vladimíra Kuglík, Petr Budinská, Eva Cejpek, Pavel Pešáková, Martina Nečesalová, Eva Relichová, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	449061
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00021808
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CGH; HR-CGH; glioblastoma multiforme; molecular cytogenetics (en)
http://linked.open.../riv/klicoveSlovo	molecular cytogenetics glioblastoma multiforme CGH HR-CGH
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[E1AB91F6FC6B]
http://linked.open...i/riv/nazevZdroje	Oncology Reports
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20B19.001
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Kuglík, Petr Veselská, Renata Vranová, Vladimíra Budinská, Eva Cejpek, Pavel Nečesalová, Eva Pešáková, Martina Relichová, Jiřina
http://linked.open...ain/vavai/riv/wos	000243611400028
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	1021-335X
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization

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