About: INTERFERENCE OF CONTAMINATED SEDIMENT EXTRACTS AND ENVIRONMENTAL POLLUTANTS WITH RETINOID SIGNALING

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Retinoids are known to regulate important processes such as differentiation, development, and embryogenesis. Some effects, such as malformations in frogs or changes in metabolism of birds, could be related to disruption of the retinoid signaling pathway by exposure to organic contaminants. A new reporter gene assay has been established for evaluation of the modulation of retinoid signaling by individual chemicals or environmental samples. The bioassay is based on the pluripotent embryonic carcinoma cell line P19 stably transfected with the firefly luciferase gene under the control of a retinoic acid responsive element (clone P19/ A15). The cell line was used to characterize the effects of individual chemicals and sediments extracts on retinoid signaling pathways. Retinoids are known to regulate important processes such as differentiation, development, and embryogenesis. Some effects, such as malformations in frogs or changes in metabolism of birds, could be related to disruption of the retinoid signaling pathway by exposure to organic contaminants. A new reporter gene assay has been established for evaluation of the modulation of retinoid signaling by individual chemicals or environmental samples. The bioassay is based on the pluripotent embryonic carcinoma cell line P19 stably transfected with the firefly luciferase gene under the control of a retinoic acid responsive element (clone P19/ A15). The cell line was used to characterize the effects of individual chemicals and sediments extracts on retinoid signaling pathways. (en)
Title	INTERFERENCE OF CONTAMINATED SEDIMENT EXTRACTS AND ENVIRONMENTAL POLLUTANTS WITH RETINOID SIGNALING INTERFERENCE OF CONTAMINATED SEDIMENT EXTRACTS AND ENVIRONMENTAL POLLUTANTS WITH RETINOID SIGNALING (en)
skos:prefLabel	INTERFERENCE OF CONTAMINATED SEDIMENT EXTRACTS AND ENVIRONMENTAL POLLUTANTS WITH RETINOID SIGNALING INTERFERENCE OF CONTAMINATED SEDIMENT EXTRACTS AND ENVIRONMENTAL POLLUTANTS WITH RETINOID SIGNALING (en)
skos:notation	RIV/00216224:14310/07:00020852!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP525/05/P160), Z(MSM0021622412)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Novák, Jiří Beníšek, Martin Bláha, Luděk Pacherník, Jiří Hilscherová, Klára Janošek, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	427152
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00020852
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Retinoid; Polycyclic aromatic hydrocarbons; 2378-Tetrachlorodibenzo-p-dioxin; Sediments; Retinoic (en)
http://linked.open.../riv/klicoveSlovo	Sediments 2378-Tetrachlorodibenzo-p-dioxin Retinoic Retinoid Polycyclic aromatic hydrocarbons
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2BED0B54E25C]
http://linked.open...i/riv/nazevZdroje	Environmental Toxicology and Chemistry
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Bláha, Luděk Hilscherová, Klára Novák, Jiří Pacherník, Jiří Beníšek, Martin Janošek, Jaroslav Giesy, John Kiviranta, Hannu Verta, Matti
http://linked.open...ain/vavai/riv/wos	000248085800005
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
issn	0730-7268
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	INTERFERENCE OF CONTAMINATED SEDIMENT EXTRACTS AND ENVIRONMENTAL POLLUTANTS WITH RETINOID SIGNALING INTERFERENCE OF CONTAMINATED SEDIMENT EXTRACTS AND ENVIRONMENTAL POLLUTANTS WITH RETINOID SIGNALING INTERFERENCE OF CONTAMINATED SEDIMENT EXTRACTS AND ENVIRONMENTAL POLLUTANTS WITH RETINOID SIGNALING

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