About: Assessment of retinoic activity in fly ash and air samples from polluted areas using P19/A15 cell line

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About: Assessment of retinoic activity in fly ash and air samples from polluted areas using P19/A15 cell line Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Contamination in the environment has been described to induce malformations in amphibians. This fact could be linked with anti/retinoic action of the contaminants because retinoids control morphogenesis by affecting processes such as differentiation or apoptosis. In vitro model for evaluation of anti/retinoic action of xenobiotics was developed. It is based on murine cell line P19, which retains a pluripotent character and its differentiation is regulated mainly by retinoids. In the derived cell line P19/A15, the retinoic response element was linked with luciferase gene enabling the study of retinoid signaling. We tested air samples extracts from two areas in the vicinity of chemical factories producing different types of pollutants, extracts from fly ash from municipal incinerator and reference sample from background locality. Important activities were observed in both gas and particulate fractions of multiple air samples and in fly ash samples. Contamination in the environment has been described to induce malformations in amphibians. This fact could be linked with anti/retinoic action of the contaminants because retinoids control morphogenesis by affecting processes such as differentiation or apoptosis. In vitro model for evaluation of anti/retinoic action of xenobiotics was developed. It is based on murine cell line P19, which retains a pluripotent character and its differentiation is regulated mainly by retinoids. In the derived cell line P19/A15, the retinoic response element was linked with luciferase gene enabling the study of retinoid signaling. We tested air samples extracts from two areas in the vicinity of chemical factories producing different types of pollutants, extracts from fly ash from municipal incinerator and reference sample from background locality. Important activities were observed in both gas and particulate fractions of multiple air samples and in fly ash samples. (en)
Title	Assessment of retinoic activity in fly ash and air samples from polluted areas using P19/A15 cell line Assessment of retinoic activity in fly ash and air samples from polluted areas using P19/A15 cell line (en)
skos:prefLabel	Assessment of retinoic activity in fly ash and air samples from polluted areas using P19/A15 cell line Assessment of retinoic activity in fly ash and air samples from polluted areas using P19/A15 cell line (en)
skos:notation	RIV/00216224:14310/07:00020343!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP525/05/P160), Z(MSM0021622412)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Novák, Jiří Beníšek, Martin Bláha, Luděk Hilscherová, Klára Štěpánková, Tereza
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	410869
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00020343
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	endocrine disruption; retinoid; complex samples (en)
http://linked.open.../riv/klicoveSlovo	retinoid endocrine disruption complex samples
http://linked.open...ontrolniKodProRIV	[A7CCB6D7C08C]
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Bláha, Luděk Giesy, John Paul Hilscherová, Klára Novák, Jiří Beníšek, Martin Štěpánková, Tereza
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
http://localhost/t...ganizacniJednotka	14310

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