About: c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	c-Jun is one of the major components of the Activating Protein-1 (AP-1), the transcription factor that participates in regulation of proliferation, differentiation and apoptosis. In this study, we explored functional interactions of the c-Jun protein with several regulators of the G1/S transition in serum-deprived v-myb-transformed chicken monoblasts BM2. We show that the c-Jun protein induces expression of cyclin A, thus up-regulating activity of cyclin A-associated cyclin-dependent kinase 2 (CDK2), and causing massive programmed cell death of starved BM2cJUN cells. Specific inhibition of CDK2 suppresses frequency of apoptosis of BM2cJUN cells. We conclude that up-regulation of cyclin A-expression and CDK2 activity can represent important link between the c-Jun protein, cell cycle machinery and programmed cell death pathway in leukemic cells. c-Jun is one of the major components of the Activating Protein-1 (AP-1), the transcription factor that participates in regulation of proliferation, differentiation and apoptosis. In this study, we explored functional interactions of the c-Jun protein with several regulators of the G1/S transition in serum-deprived v-myb-transformed chicken monoblasts BM2. We show that the c-Jun protein induces expression of cyclin A, thus up-regulating activity of cyclin A-associated cyclin-dependent kinase 2 (CDK2), and causing massive programmed cell death of starved BM2cJUN cells. Specific inhibition of CDK2 suppresses frequency of apoptosis of BM2cJUN cells. We conclude that up-regulation of cyclin A-expression and CDK2 activity can represent important link between the c-Jun protein, cell cycle machinery and programmed cell death pathway in leukemic cells. (en)
Title	c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2 c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2 (en)
skos:prefLabel	c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2 c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2 (en)
skos:notation	RIV/00216224:14310/07:00020137!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(GA301/06/0036), Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390512), Z(AV0Z50390703), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hampl, Aleš Kozubík, Alois Bryja, Vítězslav Vaňhara, Petr Horváth, Viktor Šmarda, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	413838
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00020137
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Jun; cyclin A; CDK2; apoptosis; v-myb-transformed monoblasts (en)
http://linked.open.../riv/klicoveSlovo	CDK2 cyclin A v-myb-transformed monoblasts apoptosis Jun
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[ADD123CDF374]
http://linked.open...i/riv/nazevZdroje	Biochemical and Biophysical Research Communications
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair A role of certain transcription factors in the osteoclastic differentiation pathway
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	353
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Hampl, Aleš Horváth, Viktor Kozubík, Alois Šmarda, Jan Vaňhara, Petr
http://linked.open...ain/vavai/riv/wos	000243336900015
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine Molecular basis of cell and tissue regulations
issn	0006-291X
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2 c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2 c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2

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