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Description
| - Pediatric tumors are the second main cause of childrens death in developed countries. Contrary to leukemias chromosomal alterations associated with malignant transformations are less well characterized for pediatric solid tumors. We present results of cytogenetic examinations of 262 pediatric solid tumors. Some of them were examined using by interphase fluorescent in situ hybridization (I-FISH), especially tumors where deletions or amplifications of specific genes and/or presence of fusion genes are known and could be used as diagnostic tool. Proven prognostic significance of the n-myc amplification, del 1p36, gain 17q, abnormalities on chromosome 11 are well known for children with neuroblastoma. For medulloblastomas i(17p), c-myc and i(12p) in germinal tumors are the other candidates. Vast majority of tumor samples were cultured and other possible chromosomal abnormalities were detected using FISH, spectral karyotyping (SKY) and comparative genomic hybridization (CGH). During last few months we have
- Pediatric tumors are the second main cause of childrens death in developed countries. Contrary to leukemias chromosomal alterations associated with malignant transformations are less well characterized for pediatric solid tumors. We present results of cytogenetic examinations of 262 pediatric solid tumors. Some of them were examined using by interphase fluorescent in situ hybridization (I-FISH), especially tumors where deletions or amplifications of specific genes and/or presence of fusion genes are known and could be used as diagnostic tool. Proven prognostic significance of the n-myc amplification, del 1p36, gain 17q, abnormalities on chromosome 11 are well known for children with neuroblastoma. For medulloblastomas i(17p), c-myc and i(12p) in germinal tumors are the other candidates. Vast majority of tumor samples were cultured and other possible chromosomal abnormalities were detected using FISH, spectral karyotyping (SKY) and comparative genomic hybridization (CGH). During last few months we have (en)
- Práce se zabývá detekcí chromozomových aberací ve vzorcích kultivované a nekultivované tkáně solidních dětských nádorů pomocí techniky FISH, CGH a spektrálního karyotypování (SKY) Jsou zhodnoceny cytogenetické nálezy u pacientů léčených na KDO FN Brno v letech 2003-2005. (cs)
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Title
| - Detection of chromosomal aberrations by FISH, CGH and SKY in cultured and noncultured tumours in children during 2003 and 2005
- Detection of chromosomal aberrations by FISH, CGH and SKY in cultured and noncultured tumours in children during 2003 and 2005 (en)
- Detekce chromozomových aberací u kultivovaných a nekultivovaných dětských solidních nádorů pomocí techniky FISH, CGH a SKY v průběhu let 2003 až 2005 (cs)
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skos:prefLabel
| - Detection of chromosomal aberrations by FISH, CGH and SKY in cultured and noncultured tumours in children during 2003 and 2005
- Detection of chromosomal aberrations by FISH, CGH and SKY in cultured and noncultured tumours in children during 2003 and 2005 (en)
- Detekce chromozomových aberací u kultivovaných a nekultivovaných dětských solidních nádorů pomocí techniky FISH, CGH a SKY v průběhu let 2003 až 2005 (cs)
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skos:notation
| - RIV/00216224:14310/06:00017836!RIV07-MSM-14310___
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/06:00017836
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Chromosomal aberrations; solid tumours in children; FISH; CGH; SKY (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - Europen Journal of Human Genetics
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Kuglík, Petr
- Múdry, Peter
- Vranová, Vladimíra
- Štěrba, Jaroslav
- Oltová, Alexandra
- Šmuhařová, Petra
- Žežulková, Dita
- Baičiová, Věra
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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