About: The association between high-activity COMT allele and alcoholism     Goto   Sponge   NotDistinct   Permalink

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Description
  • Objectives: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. The Val158Met polymorphism of the COMT gene has been previously associated with a variability of the COMT activity, and alcoholism. The aim of the present association study was to examine the relationship between the Val158Met polymorphism of the COMT gene and dispositions to alcoholism. Methods: In our case control study we analyzed DNA samples from 799 subjects in total (279 male alcoholics and 120 female alcoholics, 151 male controls and 249 female controls). The restriction analysis for the detection of the Val158Met polymorphism was used. Results: We found a relationship between the Val158Met polymorphism of the COMT gene and alcoholism in male subjects. We found the significant difference between male alcoholics and male controls in allele and genotype frequencies (p<0,007; and p<0,04 respectively).
  • Objectives: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. The Val158Met polymorphism of the COMT gene has been previously associated with a variability of the COMT activity, and alcoholism. The aim of the present association study was to examine the relationship between the Val158Met polymorphism of the COMT gene and dispositions to alcoholism. Methods: In our case control study we analyzed DNA samples from 799 subjects in total (279 male alcoholics and 120 female alcoholics, 151 male controls and 249 female controls). The restriction analysis for the detection of the Val158Met polymorphism was used. Results: We found a relationship between the Val158Met polymorphism of the COMT gene and alcoholism in male subjects. We found the significant difference between male alcoholics and male controls in allele and genotype frequencies (p<0,007; and p<0,04 respectively). (en)
Title
  • The association between high-activity COMT allele and alcoholism
  • The association between high-activity COMT allele and alcoholism (en)
skos:prefLabel
  • The association between high-activity COMT allele and alcoholism
  • The association between high-activity COMT allele and alcoholism (en)
skos:notation
  • RIV/00216224:14310/06:00016584!RIV10-MZ0-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR8137), V, Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 466188
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/06:00016584
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • alcohol dependence; association; COMT; Val158Met polymorphism; gene (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [0AF7306BBDE4]
http://linked.open...i/riv/nazevZdroje
  • Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Zvolský, Petr
  • Šerý, Omar
  • Mikeš, Vladimír
  • Pitelová, Renáta
  • Znojil, Vladimír
http://linked.open...n/vavai/riv/zamer
issn
  • 0172-780X
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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