About: Effect of procathepsin D activation peptide on gene expression of breast cancer cells

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Overexpression of procathepsin D (pCD) is reported to occur in numerous types of cancer and is associated with increased growth and metastasis. It has been established that pCD affects multiple stages of tumor progression including proliferation, angiogenesis and metastasis. Previously, we showed that the mitogenic effect of pCD on cancer cells is mediated by interaction of its activation peptide (AP) with yet unidentified cell surface receptor. In this investigation, gene expression profiles were compared between AP-treated and control human breast cancer ZR-75-1 cells to elucidate the mechanism of AP mitogenicity. Several differentially expressed genes involved in signal transduction, regulation of cell cycle, apoptosis, tumor invasion and metastasis were identified using microarray technology. These findings, including overexpression of NFkappaB2, were confirmed in breast cancer cell lines by reverse-transcriptase PCR (RT-PCR). Overexpression of procathepsin D (pCD) is reported to occur in numerous types of cancer and is associated with increased growth and metastasis. It has been established that pCD affects multiple stages of tumor progression including proliferation, angiogenesis and metastasis. Previously, we showed that the mitogenic effect of pCD on cancer cells is mediated by interaction of its activation peptide (AP) with yet unidentified cell surface receptor. In this investigation, gene expression profiles were compared between AP-treated and control human breast cancer ZR-75-1 cells to elucidate the mechanism of AP mitogenicity. Several differentially expressed genes involved in signal transduction, regulation of cell cycle, apoptosis, tumor invasion and metastasis were identified using microarray technology. These findings, including overexpression of NFkappaB2, were confirmed in breast cancer cell lines by reverse-transcriptase PCR (RT-PCR). (en)
Title	Effect of procathepsin D activation peptide on gene expression of breast cancer cells Effect of procathepsin D activation peptide on gene expression of breast cancer cells (en)
skos:prefLabel	Effect of procathepsin D activation peptide on gene expression of breast cancer cells Effect of procathepsin D activation peptide on gene expression of breast cancer cells (en)
skos:notation	RIV/00216224:14310/06:00016569!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1K04017), P(NR8448), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pospíšilová, Šárka Beneš, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	473170
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00016569
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Breast cancer; Gene expression; Microarray analysis; Procathepsin D (en)
http://linked.open.../riv/klicoveSlovo	Breast cancer Gene expression Procathepsin D Microarray analysis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[6CCB629C0BF1]
http://linked.open...i/riv/nazevZdroje	Cancer Letters
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Introduction of DNA microarray methodology and its application in antitumor therapy Characterization of leukemia cell gene expression using DNA microarrays and its utilization for molecular diagnostics and therapy response prediction
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	239
http://linked.open...iv/tvurceVysledku	Beneš, Petr Pospíšilová, Šárka Fusek, Martin Vashishta, Aruna Vetvicka, Václav Saraswat-Ohri, Sujata Tichy, Boris
http://linked.open...ain/vavai/riv/wos	000239553500006
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0304-3835
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Effect of procathepsin D activation peptide on gene expression of breast cancer cells Effect of procathepsin D activation peptide on gene expression of breast cancer cells

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