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  • Healthy cells strictly regulate gene transcription to control crucial cellular regulatory pathways. Members of the Jun protein family, c-Jun, JunB, and JunD are key subunits of the transcription factor AP-1 that controls transcription from various gene promoters. The genes targeted by Jun affect essential life processes, such as cell cycle progression, differentiation or programmed cell death. Therefore, the loss of proper Jun function is often associated with cancer. This review summarizes recent advances in understanding of function of the Jun proteins in healthy and cancer cells.
  • Healthy cells strictly regulate gene transcription to control crucial cellular regulatory pathways. Members of the Jun protein family, c-Jun, JunB, and JunD are key subunits of the transcription factor AP-1 that controls transcription from various gene promoters. The genes targeted by Jun affect essential life processes, such as cell cycle progression, differentiation or programmed cell death. Therefore, the loss of proper Jun function is often associated with cancer. This review summarizes recent advances in understanding of function of the Jun proteins in healthy and cancer cells. (en)
Title
  • Jun: the master regulator in healthy and cancer cells
  • Jun: the master regulator in healthy and cancer cells (en)
skos:prefLabel
  • Jun: the master regulator in healthy and cancer cells
  • Jun: the master regulator in healthy and cancer cells (en)
skos:notation
  • RIV/00216224:14310/06:00016118!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA301/06/0036), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 481109
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/06:00016118
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • AP-1; Jun; cancer; apoptosis; cell cycle; differentiation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [0F2909FA0629]
http://linked.open...i/riv/nazevZdroje
  • Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 4
http://linked.open...iv/tvurceVysledku
  • Šmarda, Jan
  • Vaňhara, Petr
http://linked.open...n/vavai/riv/zamer
issn
  • 1214-0287
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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