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Description
  • Práce se zabývá výskytem specifických chromozomových abnormalit u mozkového nádoru multiformního glioblastomu, které byly studovány pomocí techniky komparativní genomové hybridizace s vysokým rozlišením. (cs)
  • Glioblastoma multiforme (GBM) is the most common form of primary neoplasm occurring in the central nervous system of adults. The tumour can develop from a low-degree or anaplastic astrocyte secondary glioblastoma, but more frequently it manifests itself with a short clinical anamnesi as primary glioblastoma. Cytogenetic diagnostic methods form an integral part glioblastoma diagnostics, however, conventional cytogenetics has been unable to identify consistent chromosomal aberrations in this group of tumours. Thus, more advanced molecular cytogenetic approaches are required to study the relationship between chromosomal instability and patient prognosis. The aim of this study was to screen for chromosomal imbalances in GBM by CGH and modified HR-CGH. Aim was to determine chromosomal changes on primary tumours and evaluate intratumoral genetic heterogenity by comparing gains and losses of chromosomes in central and peripheral areas of tumours. In this study, chromosomal abnormalities in 22 cases of
  • Glioblastoma multiforme (GBM) is the most common form of primary neoplasm occurring in the central nervous system of adults. The tumour can develop from a low-degree or anaplastic astrocyte secondary glioblastoma, but more frequently it manifests itself with a short clinical anamnesi as primary glioblastoma. Cytogenetic diagnostic methods form an integral part glioblastoma diagnostics, however, conventional cytogenetics has been unable to identify consistent chromosomal aberrations in this group of tumours. Thus, more advanced molecular cytogenetic approaches are required to study the relationship between chromosomal instability and patient prognosis. The aim of this study was to screen for chromosomal imbalances in GBM by CGH and modified HR-CGH. Aim was to determine chromosomal changes on primary tumours and evaluate intratumoral genetic heterogenity by comparing gains and losses of chromosomes in central and peripheral areas of tumours. In this study, chromosomal abnormalities in 22 cases of (en)
Title
  • Genomic imbalance detected in glioblastoma multigorme using high-resolution comparative genomic hybridization
  • Abnormality chromozomů detegované u multiformního glioblastomu pomocí techniky komparativní genomové hybridizace s vysokým rozlišením (cs)
  • Genomic imbalance detected in glioblastoma multigorme using high-resolution comparative genomic hybridization (en)
skos:prefLabel
  • Genomic imbalance detected in glioblastoma multigorme using high-resolution comparative genomic hybridization
  • Abnormality chromozomů detegované u multiformního glioblastomu pomocí techniky komparativní genomové hybridizace s vysokým rozlišením (cs)
  • Genomic imbalance detected in glioblastoma multigorme using high-resolution comparative genomic hybridization (en)
skos:notation
  • RIV/00216224:14310/05:00014596!RIV06-MSM-14310___
http://linked.open.../vavai/riv/strany
  • 87
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(OC B19.001), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika
  • Suppl. 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 522607
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/05:00014596
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Glioblastoma multiforme; chromosome aberrations; HR-CGH; FISH (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [7E83A9D38D73]
http://linked.open...i/riv/nazevZdroje
  • Chromosome Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 13
http://linked.open...iv/tvurceVysledku
  • Kuglík, Petr
  • Vranová, Vladimíra
  • Cejpek, Pavel
  • Nečesalová, Eva
  • Pešáková, Martina
  • Relichová, Jiřina
http://linked.open...n/vavai/riv/zamer
issn
  • 9067-3849
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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