About: 3-Hydroxythiazole and 1-Hydroxyimidazole as Products of a Mutual Ring Closure Reaction. Extension to Selenium Derivatives.     Goto   Sponge   NotDistinct   Permalink

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  • A thiazole derivative can be easily prepared, e.g., from an alpha-thiocyanatoketone and a nitrogen nucleophile. In this work, alpha-bromopropiophenone was chosen as a starting compound. Since the carbonyl group facilitates nucleophilic substitution, bromine can be simply replaced with the thiocyanato group. The following reaction with hydroxylamine hydrochloride provides an intermediate, which undergoes a ring closure reaction. Finally, 3-hydroxy-5-methyl-4-phenylthiazol-2(3H)-iminium chloride or 1-hydroxy-4-methyl-5-phenyl-1,3-dihydro-2H-imidazole-2-thione arises depending on the presence of a base. In the next part, this interesting phenomenon was successfully investigated on selenium derivatives as well. All prepared substances have not been described in the literature yet.
  • A thiazole derivative can be easily prepared, e.g., from an alpha-thiocyanatoketone and a nitrogen nucleophile. In this work, alpha-bromopropiophenone was chosen as a starting compound. Since the carbonyl group facilitates nucleophilic substitution, bromine can be simply replaced with the thiocyanato group. The following reaction with hydroxylamine hydrochloride provides an intermediate, which undergoes a ring closure reaction. Finally, 3-hydroxy-5-methyl-4-phenylthiazol-2(3H)-iminium chloride or 1-hydroxy-4-methyl-5-phenyl-1,3-dihydro-2H-imidazole-2-thione arises depending on the presence of a base. In the next part, this interesting phenomenon was successfully investigated on selenium derivatives as well. All prepared substances have not been described in the literature yet. (en)
Title
  • 3-Hydroxythiazole and 1-Hydroxyimidazole as Products of a Mutual Ring Closure Reaction. Extension to Selenium Derivatives.
  • 3-Hydroxythiazole and 1-Hydroxyimidazole as Products of a Mutual Ring Closure Reaction. Extension to Selenium Derivatives. (en)
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  • 3-Hydroxythiazole and 1-Hydroxyimidazole as Products of a Mutual Ring Closure Reaction. Extension to Selenium Derivatives.
  • 3-Hydroxythiazole and 1-Hydroxyimidazole as Products of a Mutual Ring Closure Reaction. Extension to Selenium Derivatives. (en)
skos:notation
  • RIV/00216224:14310/05:00014317!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 143100011)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 552740
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/05:00014317
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Thiazole; imidazole; cyclization; selenium (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [B94C2304ED59]
http://linked.open...i/riv/nazevZdroje
  • Phosphorus, Sulfur, and Silicon and the Related Elements
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 180
http://linked.open...iv/tvurceVysledku
  • Pazdera, Pavel
  • Fajkusová, Dagmar
http://linked.open...n/vavai/riv/zamer
issn
  • 1042-6507
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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