| Attributes | Values |
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| rdf:type
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| Description
| - Human pathogenic bacterium Pseudomonas aeruginosa, which is a major cause of mortality and morbidity of cystic fibrosis patients, produces fucose-binding lectin (PA-IIL) that highly contributes to the pathogen virulence.The crystal structure of PA-IIL complexed with fucose has been solved at 1.3 A [1] and additional experiments have been performed in order to understand the molecular basis of both specificity and affinity of PA-IIL for monosaccharides. Crystals have been obtained for the protein complexed with b-Me-D-arabinopyranoside and L-galactose and structures were solved by molecular replacement. Co-crystallisation of the lectin with trisaccharides of the Lea and Lex family is being in progress.Isothermal titration microcalorimetry experiments on a series of monosaccharides sharing similar stereochemical three-hydroxyl arrangement needed for recognition were performed in order to characterize the thermodynamic parameters of the carbohydrate-lectin interaction. The stereochemical basis for the ve
- Human pathogenic bacterium Pseudomonas aeruginosa, which is a major cause of mortality and morbidity of cystic fibrosis patients, produces fucose-binding lectin (PA-IIL) that highly contributes to the pathogen virulence.The crystal structure of PA-IIL complexed with fucose has been solved at 1.3 A [1] and additional experiments have been performed in order to understand the molecular basis of both specificity and affinity of PA-IIL for monosaccharides. Crystals have been obtained for the protein complexed with b-Me-D-arabinopyranoside and L-galactose and structures were solved by molecular replacement. Co-crystallisation of the lectin with trisaccharides of the Lea and Lex family is being in progress.Isothermal titration microcalorimetry experiments on a series of monosaccharides sharing similar stereochemical three-hydroxyl arrangement needed for recognition were performed in order to characterize the thermodynamic parameters of the carbohydrate-lectin interaction. The stereochemical basis for the ve (en)
- Human pathogenic bacterium Pseudomonas aeruginosa, which is a major cause of mortality and morbidity of cystic fibrosis patients, produces fucose-binding lectin (PA-IIL) that highly contributes to the pathogen virulence.The crystal structure of PA-IIL complexed with fucose has been solved at 1.3 A [1] and additional experiments have been performed in order to understand the molecular basis of both specificity and affinity of PA-IIL for monosaccharides. Crystals have been obtained for the protein complexed with b-Me-D-arabinopyranoside and L-galactose and structures were solved by molecular replacement. Co-crystallisation of the lectin with trisaccharides of the Lea and Lex family is being in progress.Isothermal titration microcalorimetry experiments on a series of monosaccharides sharing similar stereochemical three-hydroxyl arrangement needed for recognition were performed in order to characterize the thermodynamic parameters of the carbohydrate-lectin interaction. The stereochemical basis for the ve (cs)
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| Title
| - Stereochemical basis of high affinity of Pseudomonas aeruginosa lectin for fucose : structural and thermodynamic characterisation
- Stereochemical basis of high affinity of Pseudomonas aeruginosa lectin for fucose : structural and thermodynamic characterisation (en)
- Stereochemical basis of high affinity of Pseudomonas aeruginosa lectin for fucose : structural and thermodynamic characterisation (cs)
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| skos:prefLabel
| - Stereochemical basis of high affinity of Pseudomonas aeruginosa lectin for fucose : structural and thermodynamic characterisation
- Stereochemical basis of high affinity of Pseudomonas aeruginosa lectin for fucose : structural and thermodynamic characterisation (en)
- Stereochemical basis of high affinity of Pseudomonas aeruginosa lectin for fucose : structural and thermodynamic characterisation (cs)
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| skos:notation
| - RIV/00216224:14310/03:00008871!RIV08-MSM-14310___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(ME 675), Z(MSM 143100005)
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/03:00008871
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Pseudomonas aeruginosa; lectin; microcalorimetry; crystal structure; cystic fibrosis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Imberty, Anne
- Pokorná, Martina
- Wimmerová, Michaela
- Gilboa-Garber, Nechama
- Sabin, Charles
- Gautier, Catherine
- Mitchell, Edward
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
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| http://linked.open...n/vavai/riv/zamer
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
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| http://localhost/t...ganizacniJednotka
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