About: Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis

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About: Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Development of resistance against metronidazole and mechanisms responsible for this process were studied in a sexually transmitted pathogen of humans, Trichomonas vaginalis. Monitoring of changes in metabolism and protein expression that accompanied increasing resistance of strains derived from a common drug-susceptible parent (TV 10-02) showed the multistep character of the process. The aerobic type of resistance known to occur in isolates from patients non-responsive to treatment appeared at the earliest stage, followed by development of the anaerobic type of resistance which was accompanied by gradual loss of hydrogenosomal proteins associated with drug-activating pathways [pyruvate:ferredoxin oxidoreductase (PFOR), hydrogenase, ferredoxin]. Unexpectedly, the loss of PFOR did not result in acquisition of full anaerobic resistance, thus indicating an alternative source of electrons required for the drug activation. Development of resistance against metronidazole and mechanisms responsible for this process were studied in a sexually transmitted pathogen of humans, Trichomonas vaginalis. Monitoring of changes in metabolism and protein expression that accompanied increasing resistance of strains derived from a common drug-susceptible parent (TV 10-02) showed the multistep character of the process. The aerobic type of resistance known to occur in isolates from patients non-responsive to treatment appeared at the earliest stage, followed by development of the anaerobic type of resistance which was accompanied by gradual loss of hydrogenosomal proteins associated with drug-activating pathways [pyruvate:ferredoxin oxidoreductase (PFOR), hydrogenase, ferredoxin]. Unexpectedly, the loss of PFOR did not result in acquisition of full anaerobic resistance, thus indicating an alternative source of electrons required for the drug activation. (en)
Title	Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis (en)
skos:prefLabel	Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis (en)
skos:notation	RIV/00216224:14310/02:00036243!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA204/97/0263), S, Z(MSM 113100003)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vaňáčová, Štěpánka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	652774
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/02:00036243
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Trichomonas; hydrogenosome; metronidazole; ferredoxin; PFOR; malic enzyme (en)
http://linked.open.../riv/klicoveSlovo	Trichomonas hydrogenosome PFOR metronidazole malic enzyme ferredoxin
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[FC5E7CBBF6EB]
http://linked.open...i/riv/nazevZdroje	Microbiology-UK
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanism of metronidazole resistance in trichomonads
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	148
http://linked.open...iv/tvurceVysledku	Hrdý, Ivan Tachezy, Jan Kulda, Jaroslav Vaňáčová, Štěpánka Rasoloson, Dominique Razga, Jakub Tomkova, Eva
http://linked.open...ain/vavai/riv/wos	000177529800024
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100003
issn	1350-0872
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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