About: Proteins and Their Interactions With Small Molecules Studied by Computer Simulations.

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About: Proteins and Their Interactions With Small Molecules Studied by Computer Simulations. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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Description	The presentation introduce an on-going research project focused on proteins and their interactions with small molecules. Two systems are studied by computer simulations; (1) cyclin-dependent kinase-2 (cdk2) and its inhibition by purine-like compounds, and (2) haloalkane dehalogenases. Cyclin-dependent kinases are enzymes controlling the cell division cycle. A deregulation of cdk has been proved to occur in human primary tumors and in tumor cell lines. It evoked potential application of cdk inhibitors in cancer therapy. Haloalkane dehalogenases are bacterial enzymes cleaving the carbon-halogen bond of the halogenated aliphatic compounds by a hydrolytic mechanism. These enzymes have a potential application in detoxification of subsurface pullutants and recovery of industrial side products. The presentation introduce an on-going research project focused on proteins and their interactions with small molecules. Two systems are studied by computer simulations; (1) cyclin-dependent kinase-2 (cdk2) and its inhibition by purine-like compounds, and (2) haloalkane dehalogenases. Cyclin-dependent kinases are enzymes controlling the cell division cycle. A deregulation of cdk has been proved to occur in human primary tumors and in tumor cell lines. It evoked potential application of cdk inhibitors in cancer therapy. Haloalkane dehalogenases are bacterial enzymes cleaving the carbon-halogen bond of the halogenated aliphatic compounds by a hydrolytic mechanism. These enzymes have a potential application in detoxification of subsurface pullutants and recovery of industrial side products. (en)
Title	Proteins and Their Interactions With Small Molecules Studied by Computer Simulations. Proteins and Their Interactions With Small Molecules Studied by Computer Simulations. (en)
skos:prefLabel	Proteins and Their Interactions With Small Molecules Studied by Computer Simulations. Proteins and Their Interactions With Small Molecules Studied by Computer Simulations. (en)
skos:notation	RIV/00216224:14310/02:00007233!RIV/2003/MSM/143103/N
http://linked.open.../vavai/riv/strany	45-46
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 143100005)
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Koča, Jaroslav Kříž, Zdeněk
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	660923
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/02:00007233
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Computer Simulation, Protein, Ligand (en)
http://linked.open.../riv/klicoveSlovo	Computer Simulation Protein Ligand
http://linked.open...ontrolniKodProRIV	[5C7231EE6482]
http://linked.open...v/mistoKonaniAkce	Nove Hrady
http://linked.open...i/riv/mistoVydani	Praha
http://linked.open...i/riv/nazevZdroje	Materials Structures in Chemistry, Biology, Physics and Technology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
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http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2002
http://linked.open...iv/tvurceVysledku	Damborský, Jiří Koča, Jaroslav Otyepka, Michal Strnad, Miroslav Kříž, Zdeněk
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open.../riv/zahajeniAkce	2002-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143100005
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	1. setkani ceskych a slovenskych strukturnich biologu
http://localhost/t...ganizacniJednotka	14310

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