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rdf:type
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Description
| - The XPA-RPA complex is required for initiation of mammalian nucleotide excision repair, but its molecular function during early stages of this DNA repair pathway was unknown. Here, we show that XPA-RPA constitutes a universal sensor of nucleotide damage that operates through indirect readout of DNA conformations. XPA-RPA is guided by the synergism between two different DNA binding domains: XPA recognizes abnormal bending of the deoxyribose-phosphate backbone whereas RPA recognizes base pair disruption. These two nucleic acid interaction modules are used to monitor integrity of the Watson-Crick helix by a double-check probing mechanism that confers an extremely wide recognition capacity for structural distortions. The versatility of double-check probing is confirmed by recognition and excision of platinum crosslinks with divergent conformational effects.
- The XPA-RPA complex is required for initiation of mammalian nucleotide excision repair, but its molecular function during early stages of this DNA repair pathway was unknown. Here, we show that XPA-RPA constitutes a universal sensor of nucleotide damage that operates through indirect readout of DNA conformations. XPA-RPA is guided by the synergism between two different DNA binding domains: XPA recognizes abnormal bending of the deoxyribose-phosphate backbone whereas RPA recognizes base pair disruption. These two nucleic acid interaction modules are used to monitor integrity of the Watson-Crick helix by a double-check probing mechanism that confers an extremely wide recognition capacity for structural distortions. The versatility of double-check probing is confirmed by recognition and excision of platinum crosslinks with divergent conformational effects. (en)
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Title
| - Double-check probing of DNA bending and unwinding by XPA-RPA: an architectiral function in DNA repair
- Double-check probing of DNA bending and unwinding by XPA-RPA: an architectiral function in DNA repair (en)
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skos:prefLabel
| - Double-check probing of DNA bending and unwinding by XPA-RPA: an architectiral function in DNA repair
- Double-check probing of DNA bending and unwinding by XPA-RPA: an architectiral function in DNA repair (en)
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skos:notation
| - RIV/00216224:14310/01:00004376!RIV/2002/GA0/143102/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/01:00004376
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - DNA, repair, platinum drugs, XPA protein, RPA protein (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Kasparkova, Jana
- Buterin, Tonko
- Hindges, Robert
- Hubscher, Ulrich
- Missura, Miriam
- Naegeli, Hanspeter
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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