About: Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias

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About: Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation. Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation. (en)
Title	Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias (en)
skos:prefLabel	Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias (en)
skos:notation	RIV/00216224:14310/00:00004094!RIV/2002/MSM/143102/N
http://linked.open.../vavai/riv/strany	534
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/99/0045), P(VS97032), Z(MSM 143100008)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Bajer, Milan Mezníková, Marie Hrstková, Hana Fajkus, Jiří Maláska, Jan Fajkusová, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	728983
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/00:00004094
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acute leukemias, telomerase, in situ analysis of telomeres, chemotherapy, predictive factors (en)
http://linked.open.../riv/klicoveSlovo	telomerase acute leukemias chemotherapy in situ analysis of telomeres predictive factors
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CBA50A196ECD]
http://linked.open...i/riv/nazevZdroje	Blood Cells, Molecules and Diseases
http://linked.open...in/vavai/riv/obor	FG
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Telomere dynamics in selected types of solid malignant diseases Analysis of biologically important molecular complexes
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Fajkusová, Lenka Hrstková, Hana Fajkus, Jiří Maláska, Jan Bajer, Milan Skleničková, Marie Krejčí, Kateřina
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20143100008
issn	1079-9796
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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