About: DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Modifications of natural DNA and synthetic oligodeoxyribonucleotide duplexes in a cell-free medium by analogues of antitumor cisplatin containing enantiomeric amine ligands, such as cis-[PtCl2(RR-DAB)] and cis-[PtCl2(SS-DAB)] (DAB = 2,3-diaminobutane), were studied by various methods of molecular biophysics and biophysical chemistry. The major differences resulting from the modification of DNA by the two enantiomers consist in the thermodynamical destabilization and conformational distortions induced in DNA by the 1,2-d(GpG) intrastrand cross-link. It has been suggested that these differences are associated with a different biological activity of the two enantiomers observed previously. Modifications of natural DNA and synthetic oligodeoxyribonucleotide duplexes in a cell-free medium by analogues of antitumor cisplatin containing enantiomeric amine ligands, such as cis-[PtCl2(RR-DAB)] and cis-[PtCl2(SS-DAB)] (DAB = 2,3-diaminobutane), were studied by various methods of molecular biophysics and biophysical chemistry. The major differences resulting from the modification of DNA by the two enantiomers consist in the thermodynamical destabilization and conformational distortions induced in DNA by the 1,2-d(GpG) intrastrand cross-link. It has been suggested that these differences are associated with a different biological activity of the two enantiomers observed previously. (en)
Title	DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands (en)
skos:prefLabel	DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands (en)
skos:notation	RIV/00216224:14310/00:00003309!RIV/2002/GA0/143102/N
http://linked.open.../vavai/riv/strany	2008
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA305/99/0695)
http://linked.open...iv/cisloPeriodika	78
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Brabec, Viktor Hofr, Ctirad
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	709007
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/00:00003309
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands (en)
http://linked.open.../riv/klicoveSlovo	DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[F76FDB95D6F1]
http://linked.open...i/riv/nazevZdroje	Biophysical Journal
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Affection of DNA conformation by metal-based anticancer drugs. Relations to the development of new cytostatics
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	2000
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Malina, Jaroslav Hofr, Ctirad Natile, Giovanni Maresca, Lucciana
issn	0006-3465
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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