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  • Purpose/Objectives: Appropriate determination of progression is increasingly important for evaluation of the efficacy novel treatment strategies in AA. Although RANO response criteria have been developed for contrast-enhancing high-grade gliomas, the majority of grade III tumors are minimally enhancing. Thus RANO criteria may not apply to grade III tumors. In this study, we compared progression free survival (PFS) by RANO criteria with retrospective clinical impression to evaluate utility of RANO criteria in grade III AA. Materials/Methods: We reviewed follow-up MR images for 21 consecutive patients diagnosed with AA who developed radiologically proven recurrence after irradiation at our institution. 57% had biopsy only, 33% subtotal resection and 10% of patients received gross total resection. All patients received concurrent chemoradiation with temozolomide and EBRT (median dose 59.4Gy, 33 fractions).
  • Purpose/Objectives: Appropriate determination of progression is increasingly important for evaluation of the efficacy novel treatment strategies in AA. Although RANO response criteria have been developed for contrast-enhancing high-grade gliomas, the majority of grade III tumors are minimally enhancing. Thus RANO criteria may not apply to grade III tumors. In this study, we compared progression free survival (PFS) by RANO criteria with retrospective clinical impression to evaluate utility of RANO criteria in grade III AA. Materials/Methods: We reviewed follow-up MR images for 21 consecutive patients diagnosed with AA who developed radiologically proven recurrence after irradiation at our institution. 57% had biopsy only, 33% subtotal resection and 10% of patients received gross total resection. All patients received concurrent chemoradiation with temozolomide and EBRT (median dose 59.4Gy, 33 fractions). (en)
Title
  • Evaluation of RANO Response Criteria Compared to Clinician Evaluation in Grade 3 Anaplastic Astrocytoma (AA): Implications for Clinical Trial Reporting
  • Evaluation of RANO Response Criteria Compared to Clinician Evaluation in Grade 3 Anaplastic Astrocytoma (AA): Implications for Clinical Trial Reporting (en)
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  • Evaluation of RANO Response Criteria Compared to Clinician Evaluation in Grade 3 Anaplastic Astrocytoma (AA): Implications for Clinical Trial Reporting
  • Evaluation of RANO Response Criteria Compared to Clinician Evaluation in Grade 3 Anaplastic Astrocytoma (AA): Implications for Clinical Trial Reporting (en)
skos:notation
  • RIV/00216224:14110/14:00079036!RIV15-MSM-14110___
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  • 15427
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  • RIV/00216224:14110/14:00079036
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  • RANO criteria; glioma; FLAIR failure; anaplastic astrocytoma (en)
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  • [536D71A3BB6B]
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  • Kazda, Tomáš
  • Brinkmann, D.
  • Hardie, J. G.
  • Laack, N.
  • Pafundi, D.
http://localhost/t...ganizacniJednotka
  • 14110
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