About: Modulation of induced cytotoxicity of doxorubicin by using apoferritin and liposomal cages

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About: Modulation of induced cytotoxicity of doxorubicin by using apoferritin and liposomal cages Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Doxorubicin is an effective chemotherapeutic drug, however, its toxicity is a significant limitation in therapy. Encapsulation of doxorubicin inside liposomes or ferritin cages decreases cardiotoxicity while maintaining anticancer potency. We synthesized novel apoferritin- and liposome-encapsulated forms of doxorubicin (“Apodox” and “lip-8-dox”) and compared its toxicity with doxorubicin and Myocet on prostate cell lines. Three different prostatic cell lines PNT1A, 22Rv1, and LNCaP were chosen. The toxicity of the modified doxorubicin forms was compared to conventional doxorubicin using the MTT assay, real-time cell impedance-based cell growth method (RTCA), and flow cytometry. The efficiency of doxorubicin entrapment was 56% in apoferritin cages and 42% in the liposome carrier. The accuracy of the RTCA system was verified by flow-cytometric analysis of cell viability. The doxorubicin half maximal inhibition concentrations (IC50) were determined as 170.5, 234.0, and 169. Doxorubicin is an effective chemotherapeutic drug, however, its toxicity is a significant limitation in therapy. Encapsulation of doxorubicin inside liposomes or ferritin cages decreases cardiotoxicity while maintaining anticancer potency. We synthesized novel apoferritin- and liposome-encapsulated forms of doxorubicin (“Apodox” and “lip-8-dox”) and compared its toxicity with doxorubicin and Myocet on prostate cell lines. Three different prostatic cell lines PNT1A, 22Rv1, and LNCaP were chosen. The toxicity of the modified doxorubicin forms was compared to conventional doxorubicin using the MTT assay, real-time cell impedance-based cell growth method (RTCA), and flow cytometry. The efficiency of doxorubicin entrapment was 56% in apoferritin cages and 42% in the liposome carrier. The accuracy of the RTCA system was verified by flow-cytometric analysis of cell viability. The doxorubicin half maximal inhibition concentrations (IC50) were determined as 170.5, 234.0, and 169. (en)
Title	Modulation of induced cytotoxicity of doxorubicin by using apoferritin and liposomal cages Modulation of induced cytotoxicity of doxorubicin by using apoferritin and liposomal cages (en)
skos:prefLabel	Modulation of induced cytotoxicity of doxorubicin by using apoferritin and liposomal cages Modulation of induced cytotoxicity of doxorubicin by using apoferritin and liposomal cages (en)
skos:notation	RIV/00216224:14110/14:00078586!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA14-18344S)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Skotáková, Anna Fojtů, Michaela Raudenská, Martina Gumulec, Jaromír Sztalmachová, Markéta Babula, Petr Masařík, Michal Knopfová, Lucia
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	30222
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00078586
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Apoferritin; Cancer; Cardiotoxicity; Doxorubicin; Encapsulation; Liposome; Modification (en)
http://linked.open.../riv/klicoveSlovo	Apoferritin Cancer Doxorubicin Modification Cardiotoxicity Encapsulation Liposome
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[1354BEC49C23]
http://linked.open...i/riv/nazevZdroje	International Journal of Molecular Sciences
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of nanoparticle-based cytostatics and enzymes for enhanced chemotherapy of human neuroblastomas and study of mechanisms of their action
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Babula, Petr Gumulec, Jaromír Knopfová, Lucia Kizek, Rene Masařík, Michal Sztalmachová, Markéta Kopel, Pavel Raudenská, Martina Nejdl, Lukáš Stiborova, Marie Skalickova, Sylvie Fojtů, Michaela Skotáková, Anna Vlachova, Jana
http://linked.open...ain/vavai/riv/wos	000346797400083
issn	1422-0067
number of pages	18 (xsd:int)
http://bibframe.org/vocab/doi	10.3390/ijms151222960
http://localhost/t...ganizacniJednotka	14110

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