About: Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival.

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About: Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Genetic and non-genetic predictors of 15-year survival in patients with chronic three-vessel disease (3VD) were investigated. Coronary angiography was performed on 810 subjects with symptoms of stable ischemic heart disease in 1998. The patients with 3VD were genotyped for 23 candidate polymorphisms covering the PPAR-RXR pathway, matrix metalloproteinase-2, renin-angiotensin-aldosterone system, endothelin-1, cytokine genes, MTHFR and APO E variants. Fifteen-year survival data were obtained from the national insurance registry. All data were available in the case of 150 patients with 3VD. Statistical analysis used stepwise Cox regression with dominant, recessive, or additive mode of genetic expression. Involved variables included age, sex, BMI, blood pressure, diabetes, ejection fraction, left main stenosis, previously diagnosed coronary stenosis, myocardial infarction in personal history, and coronary bypass along with polymorphisms pre-selected by log-rank tests. Genetic and non-genetic predictors of 15-year survival in patients with chronic three-vessel disease (3VD) were investigated. Coronary angiography was performed on 810 subjects with symptoms of stable ischemic heart disease in 1998. The patients with 3VD were genotyped for 23 candidate polymorphisms covering the PPAR-RXR pathway, matrix metalloproteinase-2, renin-angiotensin-aldosterone system, endothelin-1, cytokine genes, MTHFR and APO E variants. Fifteen-year survival data were obtained from the national insurance registry. All data were available in the case of 150 patients with 3VD. Statistical analysis used stepwise Cox regression with dominant, recessive, or additive mode of genetic expression. Involved variables included age, sex, BMI, blood pressure, diabetes, ejection fraction, left main stenosis, previously diagnosed coronary stenosis, myocardial infarction in personal history, and coronary bypass along with polymorphisms pre-selected by log-rank tests. (en)
Title	Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival. Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival. (en)
skos:prefLabel	Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival. Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival. (en)
skos:notation	RIV/00216224:14110/14:00078029!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123), P(VS96097)
http://linked.open...iv/cisloPeriodika	28
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Vašků, Anna Pávková Goldbergová, Monika Máchal, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	35922
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00078029
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Atherosclerosis; genetic factors; interleukin 6; survival analysis; three vessel disease (en)
http://linked.open.../riv/klicoveSlovo	three vessel disease interleukin 6 Atherosclerosis genetic factors survival analysis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[827A1F54DDE2]
http://linked.open...i/riv/nazevZdroje	Medicine
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC) Molecular pathophysiology of selected multigenic related to civilization diseases
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	93
http://linked.open...iv/tvurceVysledku	Groch, Ladislav Vašků, Anna Hlinomaz, Ota Pávková Goldbergová, Monika Máchal, Jan
http://linked.open...ain/vavai/riv/wos	000346762200030
issn	0025-7974
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1097/MD.0000000000000278
http://localhost/t...ganizacniJednotka	14110

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