About: Coincidence of ANKRD1, TMEM43and PKP2 mutations in patient with ARVD     Goto   Sponge   NotDistinct   Permalink

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  • Arrhythmogenic right ventricular dysplasia (ARVD) is a serious genetic disorder, usually with autosomal dominant inheritance, which can lead to sudden cardiac death in young individuals and athletes. The genes known to be associated with ARVD are five genes for desmosome proteins plus another three for non-desmosomal proteins. Here we present a patient with serious symptoms of ARVD (including ventricular tachycardia and sudden cardiac arrest), who carries three potentially pathological mutations in three diffe rent genes. Two missense mutations in ANKRD1 and TMEM43 gene respectively and one mutation, in PKP2, which causes aberrant splicing were detected. We hypothesized that the combination of these three pathological mutations could be the reason for the lethal course of the disease. Moreover, we assume that mutations in ANKRD1 gene, which were previously shown to be responsible for dilated cardiomyopathy and hypertrophic cardiomyopathy, could be associated also with ARVD.
  • Arrhythmogenic right ventricular dysplasia (ARVD) is a serious genetic disorder, usually with autosomal dominant inheritance, which can lead to sudden cardiac death in young individuals and athletes. The genes known to be associated with ARVD are five genes for desmosome proteins plus another three for non-desmosomal proteins. Here we present a patient with serious symptoms of ARVD (including ventricular tachycardia and sudden cardiac arrest), who carries three potentially pathological mutations in three diffe rent genes. Two missense mutations in ANKRD1 and TMEM43 gene respectively and one mutation, in PKP2, which causes aberrant splicing were detected. We hypothesized that the combination of these three pathological mutations could be the reason for the lethal course of the disease. Moreover, we assume that mutations in ANKRD1 gene, which were previously shown to be responsible for dilated cardiomyopathy and hypertrophic cardiomyopathy, could be associated also with ARVD. (en)
Title
  • Coincidence of ANKRD1, TMEM43and PKP2 mutations in patient with ARVD
  • Coincidence of ANKRD1, TMEM43and PKP2 mutations in patient with ARVD (en)
skos:prefLabel
  • Coincidence of ANKRD1, TMEM43and PKP2 mutations in patient with ARVD
  • Coincidence of ANKRD1, TMEM43and PKP2 mutations in patient with ARVD (en)
skos:notation
  • RIV/00216224:14110/14:00077661!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 7710
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/14:00077661
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • ANKRD1; Arrhythmogenic right ventricular dysplasia; Cardiomyopathy; Next generation sequencing; PKP2; TMEM43 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CA - Kanada
http://linked.open...ontrolniKodProRIV
  • [C096E2CD3D51]
http://linked.open...i/riv/nazevZdroje
  • Experimental and Clinical Cardiology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 20
http://linked.open...iv/tvurceVysledku
  • Hrstková, Hana
  • Grochová, Diana
  • Grochová, Ilga
  • Skutková, Linda
issn
  • 1205-6626
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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