About: Increased mean platelet volume and immature platelet fraction as potential predictors of thrombotic complications in BCR/ABL-negative myeloproliferative neoplasms

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About: Increased mean platelet volume and immature platelet fraction as potential predictors of thrombotic complications in BCR/ABL-negative myeloproliferative neoplasms Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	BCR/ABL-negative myeloproliferative neo¬plasms (MPNs) are considered to be acquired thrombo-philic conditions. Persistently enhanced platelet activation has been described in polycythaemia vera and essential thrombocythaemia (ET), and shown to contribute to a higher risk of arterial and venous thrombotic complica-tions. Recent studies have shown that mean platelet volume (MPV) and immature platelet fraction (1PF) can serve as useful markers of platelet activation and increased risk of thrombosis. The aim of the present study was to investigate the relationship between these parameters and thrombotic events in BCR/ABL-negative MPN. MPV values in patients with BCR/ABL-negative MPN were significantly higher than MPV values of healthy individuals (P < 0.001). No significant difference in MPV or IPF was observed between groups of patients with and without thrombotic complications (P = 0.441; P = 0.110); the difference in IPF values was close to the significance level for patients with ET (P = 0.073). BCR/ABL-negative myeloproliferative neo¬plasms (MPNs) are considered to be acquired thrombo-philic conditions. Persistently enhanced platelet activation has been described in polycythaemia vera and essential thrombocythaemia (ET), and shown to contribute to a higher risk of arterial and venous thrombotic complica-tions. Recent studies have shown that mean platelet volume (MPV) and immature platelet fraction (1PF) can serve as useful markers of platelet activation and increased risk of thrombosis. The aim of the present study was to investigate the relationship between these parameters and thrombotic events in BCR/ABL-negative MPN. MPV values in patients with BCR/ABL-negative MPN were significantly higher than MPV values of healthy individuals (P < 0.001). No significant difference in MPV or IPF was observed between groups of patients with and without thrombotic complications (P = 0.441; P = 0.110); the difference in IPF values was close to the significance level for patients with ET (P = 0.073). (en)
Title	Increased mean platelet volume and immature platelet fraction as potential predictors of thrombotic complications in BCR/ABL-negative myeloproliferative neoplasms Increased mean platelet volume and immature platelet fraction as potential predictors of thrombotic complications in BCR/ABL-negative myeloproliferative neoplasms (en)
skos:prefLabel	Increased mean platelet volume and immature platelet fraction as potential predictors of thrombotic complications in BCR/ABL-negative myeloproliferative neoplasms Increased mean platelet volume and immature platelet fraction as potential predictors of thrombotic complications in BCR/ABL-negative myeloproliferative neoplasms (en)
skos:notation	RIV/00216224:14110/14:00077527!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Penka, Miroslav Kissová, Jarmila Bourková, Ludmila Ovesná, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	21150
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00077527
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Mean platelet volume (MPV); Immature platelet fraction (IPF); BCR/ABL-negative myeloproliferative neoplasms (MPN); Thrombosis (en)
http://linked.open.../riv/klicoveSlovo	BCR/ABL-negative myeloproliferative neoplasms (MPN) Immature platelet fraction (IPF) Mean platelet volume (MPV) Thrombosis
http://linked.open...odStatuVydavatele	JP - Japonsko
http://linked.open...ontrolniKodProRIV	[FAA489CCA8A6]
http://linked.open...i/riv/nazevZdroje	International Journal of Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	100
http://linked.open...iv/tvurceVysledku	Kissová, Jarmila Ovesná, Petra Penka, Miroslav Bourková, Ludmila Buliková, Alena
http://linked.open...ain/vavai/riv/wos	000345079600004
issn	0925-5710
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s12185-014-1673-0
http://localhost/t...ganizacniJednotka	14110

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