About: Cereblon - nový terapeutický ciel' v liečbe mnohopočetného myelómu     Goto   Sponge   NotDistinct   Permalink

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Description
  • Treatment of multiple myeloma (MM), currently an incurable disease, aims to achieve complete remission. Immunomodulatory drugs (IMiDs), represented by thalidomide, are one class of very effective drugs. However, the mechanism of IMiDs action is not yet completely understood. Recent research suggests that cereblon (CRBN) plays an important role in mediating anti-tumor effects of IMiDs; therefore, our review focuses on this protein. CRBN is a substrate receptor of Cul4-E3 ubiquitin ligase complex, and thus recognizes proteins destined for degradation. Binding of CRBN and IMiDs inhibits function of the entire ubiquitin-proteasome complex which partly explains their anti-tumor effects. In addition, a correlation between CfiB/V gene expression and effectiveness of treatment in MM patients treated with IMiDs was confirmed. These findings suggest that CRBN expression could possibly serve as a biomarker to predict response to IMiD in MM patients. (en)
  • Liečba mnohopočetného myelómu (multiple myeloma - MM), v súčasnosti nevyliečitelhého ochorenia, sa zameriava na dosiahnutie kompletnej remisie. Jednou skupinou liekov, ktorá je v tomto ohlade poměrné efektívna, sú imunomodulačné lieky (immunomodulatory drugs -IMiDs) ako napr. talidomid. Mechanizmus ich účinku však nieje doposial'úplné jasný. Posledně výskumy naznačujú, že dóležitú úlohu v sprostredkovaní protinádorových účinkov IMiDs zohráva protein cereblon (CRBN), na ktorý sa v tomto přehradovém článku zameriavame. Tento protein má funkciu substrátového receptoru v Cul4-E3 ubikvitín-proteín ligázovom komplexe, a teda rozpoznává proteiny určené k degradácií. Vazbou CRBN a IMiDs sa inhibuje funkcia celého ubikvitín-proteazómového komplexu, co vysvětluje ich protinádorové účinky. Okrem toho bola potvrdená aj korelácia medzi expresiou genu CRBN a efektivitou liečby u MM pacientov Mečených IMiDs.
Title
  • Cereblon - nový terapeutický ciel' v liečbe mnohopočetného myelómu
  • Cereblon - a New Target of Therapy in the Treatment of Multiple Myeloma (en)
skos:prefLabel
  • Cereblon - nový terapeutický ciel' v liečbe mnohopočetného myelómu
  • Cereblon - a New Target of Therapy in the Treatment of Multiple Myeloma (en)
skos:notation
  • RIV/00216224:14110/14:00077215!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
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  • I
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http://linked.open...titaPredkladatele
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  • 6510
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/14:00077215
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http://linked.open.../riv/klicovaSlova
  • cereblon; multiple myeloma; immunomodulatory drugs (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [44EB980815C4]
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  • Klinická onkologie
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http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Hájek, Roman
  • Ševčíková, Sabina
  • Sedlaříková, Lenka
  • Bešše, Lenka
  • Stanková, Monika
  • Vrábel, Dávid
issn
  • 0862-495X
number of pages
http://bibframe.org/vocab/doi
  • 10.14735/amko2014326
http://localhost/t...ganizacniJednotka
  • 14110
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